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You are viewing titles for UNIVERSITY OF PENNSYLVANIA in the Cellular biology available through the UMI Dissertations & Thesis Gradwoorks site
 
Biological molecules as protectors against cellular damage caused by environmental extremes: The role of protectant-water interactions
Counting up off schedule: Investigating the timing of developmental transitions in the Drosophila testis
 
In silico analysis of microbial biosynthetic capabilities at the genome-scale
Helminth antigens modulate TLR-ligand induced dendritic cell activation
 
Dealing with stress: Human cytomegalovirus maintains translation in cells under adverse conditions
SLP-76: Complex regulation of FcepsilonRI signaling in mast cells
 
The effects of disruption of cytoskeleton polymers on the rheological properties of cultured mammalian cells in the cortical and perinuclear regions
The role of the exocyst complex in polarized exocytosis
 
Regulation of immunoreceptor and integrin signaling by the adapter protein SLP-76
The dynamics of immunosurveillance in pancreatic cancer from inception to invasion and metastasis
 
HIF-1alpha and HIF-2alpha have opposite effects on c-Myc implications for normal and transformed cell proliferation
Notch signaling in cardiac development
 
Non-clathrin endocytosis: Mechanisms of regulating Arf6 and its endocytic pathway
Interplay between SCF and CDK complexes in the control of cellular proliferation
 
Role of exocytosis in cell polarization
Regulation of circadian rhythms and adipogenesis by the nuclear receptor Rev-erbalpha
 
Development and application of Tat-near-infrared-emissive polymersomes for in vivo optical imaging of dendritic cells
Allocating energy utilization for growth and metabolism: The interplay between insulin and inflammatory signaling in Drosophila melanogaster
 
Calcium buffering in the chick cochlear hair cell active zone
Integration of growth factor and nutrient signaling in the regulation of cellular and organismal growth
 
Diversity in molecular recognition of phospholipids by PH domains: An examination of three unusual PH domain-phospholipid interactions
Roles of dynein and dynactin in cell migration and disease
 
The winged helix transcription factor Foxl1 in proliferation and homeostasis of the gastrointestinal tract and liver
Regulated protein sorting in the endosomal system
 
Influence of Tie2 on tumor vascular signaling, integrity, and response to therapy
Aging and T cell development: Role of the hematopoietic stem cell and downstream T progenitors in bone marrow and thymus
 
Regulation of coreceptor gene transcription and CD4/CD8 lineage choice in the thymus
The absolute quantification of focal adhesion kinase activation loop phosphorylation by liquid chromatography-mass spectrometry: A biomarker of Src kinase activity
 
PERK-regulated protein translation mediates cell cycle arrest and survival during the Unfolded Protein Response
Characterizing the role of the exocyst component Exo70 in exocytosis and actin dynamics in budding yeast Saccharomyces cerevisiae
 
Developmental-associated differences in membrane cholesterol content play a defining role in the response of transitional immature and mature B cells upon B cell receptor engagement
Bi-directional astrocyte-neuron signaling in the hippocampus: Gq-coupled receptor activation mediates astrocytic Ca2+ and purinergic gliotransmission
 
Extracellular matrix stiffness augments integrin and growth factor receptor signaling to drive malignant transformation
The emergence of embryonic dorsal-ventral pattern through the interactions of BMP ligands with their receptors and modulators
 
The role of an asymmetric T lymphocyte division in generating diversity during adaptive immune responses
Signaling pathways regulating amyloid precursor protein and Abeta generation: Roles for isoprostane-induced thromboxane receptor signaling and chronic Akt activation in Alzheimer's disease
 
The role of lymphoid-resident and migratory dendritic cell subsets in shaping the primary CD4+ T cell response
Insulin regulates adipocyte lipolysis via a compartmentalized Akt-independent signaling pathway
 
Multi-site analyses of endothelial phenotypes at locations of varying susceptibilities to atherogenesis in normal and hypercholesterolemic swine
Proteolytic processing of the guidance receptor Roundabout regulates its activity
 
DNA damage response pathways in cancer chemotherapy: Investigating roles of PARP and PP2A
Ars2 links the nuclear cap binding complex to RNA processing and cell proliferation
 
Akt signaling maintains survival and proliferation in immature T cells and hematopoietic stem cells
Molecular mechanisms of calcium-evoked chloride and bicarbonate secretion from murine airway submucosal gland serous acinar cells
 
The subversion of Treg-mediated transplantation tolerance by Toll-like receptor signals
Novel contributions of Pdx-1 to pancreatic beta-cell adaptation to insulin resistance
 
Ezrin and moesin are required for T cell function
Tonic B cell antigen receptor signals supply an NF-kappa substrate, p100, for prosurvival BLyS signaling
 
Spatial regulation of Cdc42 by its GTPase-activating proteins Rga1 and Bem2 in budding yeast Saccharomyces cerevisiae
Roles for TACI, a BLyS receptor, in toll-like receptor stimulated B cells and marginal zone fitness
 
Maternal depletion of CTCF reveals multiple functions in transcription and development
Functional characterization of Alpha Hemoglobin Stabilizing Protein in hemoglobin synthesis
 
Loss of PDCD4 results in insulin resistance through ER stress
Regulation of T cell receptor and integrin function by the adaptor protein SH2-containing leukocyte phosphoprotein of 76 kDa SLP-76
 
Hypoxia Inducible Factors regulate the p53 and notch pathways to promote cancer
ATR and H2AX cooperate in maintaining genome stability under replication stress
 
Membrane protein sorting and trafficking in budding yeast Saccharomyces cerevisiae endocytic system
Regulation of H2AX phosphorylation density around a defined double stranded DNA break in chromatin
 
Role of the F-BAR protein Hof-1 in the regulation of chitin synthesis and cytokinesis in yeast
Carbon-based nanoprobes for cell nanosurgery & biological applications
 
Functional characterization of the self signal CD47: From macrophage clearance mechanisms to therapeutic development
Cooperative relationships between Brca2, timeless, and other genome maintenance regulators for ensuring genomic integrity during DNA replication
 
Regulation and functions of TRE17/ubiquitin-specific protease 6 (USP6) oncogene in aneurysmal bone cyst
Quantitative analysis of immune cell motility and mechanics on hydrogel substrates
 
unplugged/MuSK signaling coordinates pre- and postsynaptic development at the neuromuscular junction
RNA-dependent recruitment of ORC to the Epstein-Barr virus origin of replication
 
Constitutive non-canonical NF-kappaB signaling in pancreatic cancer
Coxsackievirus B3 entry into non-polarized HeLa cells
 
The circadian clock as a sensor of cell metabolic state: Interactions between nutrients, growth factors, and the mammalian clock machinery
Mass spectrometry-based proteomics reveals distinct mechanisms of astrocyte protein secretion
 
A systems approach to cellular signal transduction
K-Ras oncogene-induced ROS detoxification promotes tumorigenesis
 
Enhancement of immune responses to DNA vaccines
Molecular mechanisms of the Birt-Hogg-Dube tumor suppressor
 
YY1 functions in B lymphocyte development
Control of denticle diversity in the Drosophila embryo
 
The role of Akt2 in hepatic lipid metabolism
The C1 domain in cancer signaling molecules: Regulation by lipids and protein-protein interactions
 
Protein Partners and Post-translational Modifications: Towards Understanding the Regulation of Argonaute Proteins
Cellular and molecular analyses of neural and synaptic development in zebrafish
 
Lin28B, let-7, and the molecular pathogenesis of colon cancer
Molecular functions of the TRE17/ubiquitin-specific protease 6 (USP6) oncogene: A novel activator of NF-kappa B
 
The basis of VCP-mediated degeneration: Insights from a Drosophila model of disease
The role of preMBT transcription in Xenopus development
 
A study of the Ebola virus glycoprotein: Disruption of host surface protein function and evasion of immune responses
The role of the exocyst in exocytosis and cell migration
 
The evolution of platelet responses to collagen under conditions of hemodynamic flow
The role of SLP-76 phosphotyrosines in TCR signal transduction and T cell differentiation
 
Identification of cell migratory cues by control of microenvironmental adhesion
The Role of Wnt Signaling in Oligodendrocyte Development
 
Regulation of TGF-B1-induced apoptosis and epithelial-mesenchymal transition by matrix rigidity
The fibronectin EIIIA splice variant promotes hepatic stellate cell motility and liver fibrosis via alpha9beta1 integrin
 
Ubiquitination and Deubiquitination in Cellular Responses
Dissecting the PMEL amyloid: An example of functional vs. pathological amyloid
 
Regulation of contractility in mammalian cells by soluble, adhesive and mechanical cues of the microenvironment
Tumorigenic adenovirus 12 cells evade NK lysis by reducing the expression of NKG2D ligands
 
Fatty Acid Metabolism Mediated by 12/15-Lipoxygenase is a Novel Regulator of Hematopoietic Stem Cell Function and Myelopoiesis
Structural, biochemical, and cell biological characterization of RAB7 mutants that cause peripheral neuropathy
 
Extracellular leucine-rich repeat protein LET-4 is required to organize the extracellular matrix and maintain junctions in C. elegans epithelia
The cytoskeletal mechanisms of cell-cell junction formation in endothelial cells
 
Regional lysosomal malfunction underlies the selectivity of alpha-synuclein neurodegeneration
Interleukin-22 regulates immunity, inflammation and tissue homeostasis at mucosal sites
 
The EGF-Ras-Erk pathway and the Nkx-5/HMX homeodomain protein MLS-2 promote tube development in the C.elegans excretory system
Asymmetric T cell division and the self-renewal of specific immunity
 
Cellular characterization of the receptors for the C5a anaphylatoxin and their contributions to the innate and adaptive immune responses
Inducible deletion of Dicer or Drosha reveals multiple functions for miRNAs in postnatal epidermis and hair follicles
 
Signals controlling regulatory T cell differentiation and homeostasis
Induction of cellular senescence as a novel therapeutic strategy for melanoma treatment
 
Engineering hyaluronic acid hydrogel degradation to control cellular interactions and adult stem cell fate in 3D
Spatially and temporally controlled mechanical signals to direct human mesenchymal stem cell behavior
 
HIV-induced cellular reprogramming: insights from phosphoproteomics
Matrix elasticity drives cytoskeletal polarization and guides stem cell migration
 
Periostin and its role in promoting invasion in the tumor microenvironment of esophageal cancer