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You are viewing titles for UNIVERSITY OF MICHIGAN in the Pharmaceutical Chemistry available through the UMI Dissertations & Thesis Gradwoorks site
 
Development of nanoparticle based tools for reactive oxygen species and related biomedical applications
 Small molecule transcriptional activation domains
 
A novel approach to formulation of anticancer drugs in nanoparticles
 Understanding the mechanisms, thermodynamics and kinetics of cocrystallization to control phase transformations
 
The pharmacokinetics and pharmacodynamics of CNS-acting agents
 Design, synthesis and biological evaluation of non-peptidic small molecular Smac mimetics as potent IAP inhibitors
 
Thermodynamic and kinetic parameters that explain crystallization and solubility of pharmaceutical cocrystals
 I. Novel instructional technology tools in teaching pharmaceutical analysis laboratories. II. New approaches towards the synthesis of sugar amino-acids
 
Structure based design of peptide-mimetic STAT3 inhibitors
 Elucidation of anti-proliferative and pro-apoptotic signaling induced by the immunomodulatory benzodiazepine Bz-423
 
Controlled release of angiogenic growth factors from poly(lactic-co-glycolic acid) implants for therapeutic angiogenesis
 Ruthenium-catalyzed metathesis with directly functionalized olefins
 
The impact of molecular complexation on intestinal membrane permeation
 The synthesis and exploration of potential new antagonists of the Wnt signaling pathway: New leads to treat colon cancer? Or, not quite?
 
SMARTS approach to chemical data mining and physicochemical property prediction
 Targeting the BCL9/B9L binding interaction with beta-catenin as a potential anticancer strategy
 
Intestinal absorption of low permeability drugs: A transporter- and enzyme-targeted approach
 Potential anti-thrombotic nitric oxide generating layer-by-layer assembly
 
Development and characterization of microscale samplers coupled to HPLC for near real-time reaction monitoring
 Structure based design of peptidomimetic inhibitors of the MLL1-WDR5 interaction
 
Role of peptide transporter PEPT1 in the intestinal absorption and pharmacokinetics of the amino acid ester prodrug valacyclover
 Understanding the solution phase chemistry and solid state thermodynamic behavior of pharmaceutical cocrystals