ProQuest Subject Index - Biochemistry at UNIVERSITY OF MICHIGAN

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You are viewing titles for UNIVERSITY OF MICHIGAN in the Biochemistry available through the UMI Dissertations & Thesis Gradwoorks site

Peptides as model systems, antimicrobial agents, and a means for protein superassembly	Biosynthetic innovation on a polyketide assembly line: Biochemical studies of curacin A pathway

Mechanistic investigations of transcriptional activator function for the design of synthetic replacements	Structure, function, and dynamics of minimal and extended hammerhead ribozymes

Investigating kissing to duplex dimer transition mechanism of HIV-1 SL1 by NMR	Flavoenzymes involved in pyrimidine oxidation and reduction

Folding and conformational dynamics of the hairpin ribozyme and the spliceosome: Combining computational and experimental analyses	Investigation of the RNA-protein interactions in bacterial ribonuclease P (RNase P)

CHD8, a novel ATP-dependent chromatin remodeling enzyme	Characterization of amyloid-beta interactions at the membrane interface: Implications for pathogenesis

Studies of 3-Deoxy-D-manno-octulosonate 8-phosphate phosphatase: Mechanistic insights and a gene fusion example	Perturbations of cellular membranes with synthetic polymers and ultrafast lasers

The differences are in the details: The mechanism of flavin reduction in Class 1A and Class 2 dihydroorotate dehydrogenases	Single molecule characterization of the Varkud Satellite ribozyme and bulk native purification of non-coding RNA

Probing lymphocyte responses to modulation of the F0F1-ATPase by BZ-423	Mechanistic studies on AdoCbl-dependent glutamate mutase

Biochemical, structural, and bioengineering studies of cytochrome P450 enzymes involved in biosynthesis of secondary metabolites	Pancreatic islet amyloid polypeptide membrane binding and permeabilization

Kinetic mechanism for binding and flipping of damaged bases by alkyladenine DNA glycosylase	Structure, mechanism and regulation of homocitrate synthase

Regulation of androgen-responsive transcription by the chromatin remodeling enzyme CHD8	Characterizing HIV-1 transactivation response element dynamics that govern ligand recognition: Direct applications to drug discovery

Characterization and analysis of biosynthetic systems from Nostoc sp. ATCC 53789 and selected fungal natural product pathways	Characterization of RPE65 and RDH12, two enzymes associated with retinal dystrophy and retinoid processing

A NMR investigation of structure and allostery in the Hsp70 chaperone system	Molecular mechanisms of growth hormone-induced signal transduction and SH2B1beta-mediated regulation of the actin cytoskeleton

Characterization of the dynamic interactions of transcriptional activators	Pyrroloquinoline quinone (PQQ) labeling moieties for the sensitive detection of biomolecules

Development of novel tandem mass spectrometric strategies towards LC/FT-ICR MS-based structural determination in metabolomic and peptidomic analysis	Characterization of the redox switches in human heme oxygenase-2 and a human heme-responsive potassium channel

Target identification and validation of a novel family of anti-inflammatory 1,4-benzodiazepine-2,5-diones	Solid state NMR investigations of lipid bilayers and biomembrane binding molecules: Dendrimers and amylin

Molecular engineering of a banana lectin that inhibits HIV-1 replication	Kinase inhibitors as mediators of neuronal differentiation

Development of a novel protein sensor for the intracellular imaging of zinc	Development of small molecule RGS inhibitors as a mechanism to modulate G-protein signaling

Development and implementation of in vivo crosslinking for identifying protein targets of the transcriptional activator Gal4	Expanding the repertoire of chemical modulators for heat shock protein 70 (Hsp70): New probes for neurodegenerative disease

Regulation of apical polarity complexes	Thiol-mediated redox modulation of the adaptive immune response

Evolution of eukaryal tRNA-guanine transglycosylase: Insight gained from the characterization of the human and Escherichia coli tRNA-guanine transglycosylases	Studies of molecular mechanisms of synthetic antimicrobial compounds using sum frequency generation vibrational spectroscopy

Shining Light On Dim2: Dissecting the Roles of an RNA-Binding Protein in Ribosomal Small Subunit Assembly	In vivo neurochemical monitoring with high temporal and spatial resolution using segmented flow microfluidics

Crystal structures of GfcC, a group 4 capsule operon protein from Escherichia coli, and YraM, an outer membrane lipoprotein from Haemophilus influenzae	Conformation-Specific Chemical Probes for Amyloid-beta

Upstream components of mTORC1	Spatially Controlled Organic/Inorganic Hybrids Designed to Enhance Cellular Response

Symmetry Assembled Supramolecular Protein Cages: Investigating a Strategy for Constructing New Biomaterials	Investigation into the Activity and Specificity of the Thioesterase II, Ketoreductase and Dehydratase Domains of Multiple Polyketide Synthases

Sum Frequency Generation and Molecular Dynamics Studies of Biomolecular Orientation at Model Interfaces	High Throughput Screens Against Heat Shock Protein 70 (Hsp70)

The reactions of flavin-dependent thymidylate synthase from Thermotoga maritima	I. Synthesizing and Identifying Small Molecule Probes for Targeting Transcriptional Co-factors. II. Design and Implementation of a Peer-Led Practical Research Ethics Module for Teaching Graduate Research Ethics

Developing Tools to Investigate Protein Sulfenylation in Living Cells	Molecular Architecture of a 40S Ribosomal Subunit Maturation Intermediate

Construction and screening of custom peptide libraries derived from synthetic DNA pools	Structural Investigation of Helical Intermediates in the Misfolding Pathway of Amyloid Peptides Associated with Type II Diabetes and HIV

The Development of Reactions for the Stereoselective Synthesis of Heterocycles and Benzylic Amines, and Exploration of Bisisoxazolidines as Small Molecule Transcriptional Activation Domains	Specialized metabolites and related biosynthetic enzymes in tomato glandular trichomes: Defining biological functions of specific gland types

Characterizaiton of the ATP-Dependent Chromatin Remodeling Enzyme CHD8	Nitric oxide therapies for local inhibition of platelets' activitation on blood-contacting surfaces

Reducing the mysteries of sulfur metabolism in Mycobacterium tuberculosis	Structural Basis and Functional Consequences of Alternative ATF2-Jun Heterodimer Orientations at the Interferon-beta Enhancer

Development and application of metabolomic techniques for identification and quantification of intercellular metabolites relevant to glucose stimulated insulin secretion in beta-cells	I. The Utility of Activation Domain Mimics as Targeted Inhibitors of Transcription II. The Design and Implementation of a Peer-Led Module in Practical Research Ethics

The Double Helix in Motion: New Insights into Sequence-specific, Functional DNA Dynamics Using NMR Spectroscopy	Exogenous Control of the Assembly of Transcriptional Complexes at Gene Promoters

Elucidating the Role of Protein Sulfenylation in Eukaryotic Signal Transduction	Identification and Characterization of Oxalate Oxidoreductase, a Novel Thiamine Pyrophosphate-dependent Enzyme that Enables Anaerobic Growth on Oxalate

Synthesis of Tritium Labeled Queuine, PreQ1 and Related Azide Probes Toward Examining the Prevalence of Queuine	Chaperone-dependent Ubiquitination of Neuronal Nitric Oxide Synthase

Characterization of the Amyloidogenic Peptides Amylin & PAP248-286	Metal-oxide enrichment and gas-phase characterization of sulfopeptides using Fourier transform ion cyclotron resonance mass spectrometry

Implementation and Optimization of an in vivo Photo-crosslinking Methodology to Define Direct Targets of Transcriptional Activators	Spatial coordination of tRNA genes

Characterization of Human Hsp70 Chaperone Complexes and Chemical Control Over Their Formation	Probing microRNA Activity in vitro and inside Cells Using Single Molecule Microscopy

Secondary Structure of Bacteriophage T4 Gene 60 mRNA: Implications for Translational Bypassing	Exploiting the Bioenergetics of Disease-Causing Lymphocytes for Selective Immunomodulation

Biochemical and structural studies of aminoglycoside acetyltransferases	Structural and Thermodynamic Investigation into the Effects of Protein Fluorination

In vitro characterization of wild-type and rifamycin-resistant Mycobacterium tuberculosis RNA polymerases	Investigation of the Formation of Z-DNA and Other Non-Canonical DNA Conformations Using a Combined Spectroscopic and Biochemical Approach

An investigation of the roles of magnesium ions in the catalytic cycle of the protein kinase CDK2: A molecular link between allosteric activation and catalytic activity	Inhibiting Protein-Protein Interactions in the Hsp70 Complex as a Means to Regulate Protein Homeostasis

Studying zinc homeostasis in Escherichia coli using carbonic anhydrase-based ratiometric sensors	Investigating the effects and mechanisms of interaction between cytochrome P450 2B4, cytochrome P450 2E1 and cytochrome P450 reductase

The packaging of 7SL RNA by HIV-1	Detailed Analysis of Biosynthetic Components for the Virulence-Associated Siderophore Petrobactin from Bacillus anthracis

Neural Biosensor Probes for Simultaneous Electrophysiological Recordings, Neurochemical Measurements, and Drug Delivery with High Spatial and Temporal Resolution	(1) The Relationship of Protein Expression and Cell Division, (2) 3D Imaging of Cells Using Digital Holography, and (3) General Chemistry Enrollment at University of Michigan

Dynamics of mineralization during bone development