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You are viewing titles for UNIVERSITY OF CALIFORNIA SAN DIEGO in the Biochemistry available through the UMI Dissertations & Thesis Gradwoorks site
 
Microscopic studies in nascent frustule formation from protoplasts of the marine pennate apochlorotic diatom Nitzschia alba and production of novel transformation vectors for studies in N. alba and the marine centric photoautotrophic diatom Thalassiosira pseudonana
Comparison between rabbit and bovine skeletal muscle PFK-1 inhibition in relation to the conditions for muscle glycogen synthesis
 
Investigation of substrate phosphorylation by and subcellular localization of SR protein kinase 1
Characterization of the RRM2 domain of splicing factor ASF/SF2
 
Maturation of single retinogeniculate projections visualized by in vivo electroporation of fluorescent proteins
Ultraviolet resonance Raman spectroscopy of the integral membrane protein OmpA: Elucidating structure and tryptophan microenvironment of folded and unfolded states
 
The Psuedomonas syringae type III effector HopE1 interacts and inhibits an Arabidopsis WNK kinase
Mass spectrometric and bioinformatics approaches to characterizing of cyclic non-ribosomal peptides and ribosomally encoded peptide antibiotic
 
Genesis of the 1918 H1N1 Spanish influenza into the 2009 swine origin influenza
Enzyme replacement therapy for Pompe disease
 
The calcification of Staphylococcus aureus bacteria: A potential defense mechanism against infections
The importance of histidine 197 in Escherichia coli release factor 1 and the nucleotide dependence of release factor 3
 
Characterization of the Archaebacterial Ortholog of the Processing Body Subunit Winnebago/Growl
Evaluating cell-free expression of human integral membrane proteins for structural studies by NMR spectroscopy
 
The Response of Fatty Acids and Pigments to Variations in Temperature and Irradiance in the Marine Diatom Thalassiosira pseudonana
Probing the Nonribosomal Peptide Synthetase Epimerization Domain via Rationally Designed Suicide Inhibitors
 
Rapid Detection of Thrombin and Other Protease Activity Directly in Whole Blood
An efficient algorithm combining cell multipole and multigrid methods for rapid evaluation of dipole iteration in polarizable force fields
 
Biophysical characterization of NEMO and IKK2
Kinetics and mechanism of the interaction of the C1 domain of protein kinase C with lipid membranes
 
Energy landscapes for protein folding, binding, and aggregation: Simple funnels and beyond
Biochemical and biophysical characterization of the manganese transport regulator (MntR) from Bacillus subtilis
 
Functional analysis of the ubiquitin ligase Hrd1p with the ubiquitin-conjugating enzyme Ubc7p
Biochemical characterization of matrix Gla protein
 
Heterocyclic metal-binding groups for matrix metalloproteinase and anthrax lethal factor inhibition
Conformational dynamics of interleukin-1beta and protein-membrane interactions
 
Aminoglycoside derivatives and mimetics as RNA binders
Characterization of IDI2, a second isopentenyl diphosphate in mammals
 
Applications of nuclear magnetic resonance spectroscopy to membrane protein structure determination
Characterization of mRNA splicing factors: ASF/SF2 and Ire1p
 
Inferring interactions and functions of proteins using evolutionary information
X-ray crystallographic and biochemical studies on the bone morphogenetic protein family
 
Targeting unique nucleic acid structures with small molecules
Investigation of the potential anticancer and antifungal active secondary metabolites from marine natural products
 
Bioinorganic tools and zinc selective inhibitors for matrix metalloproteinases
Mechanistic characterization of Csk: The role of structural transitions and inter-domain crosstalk in enzyme function
 
Protein-protein interactions of the LRP1 cytoplasmic domain modulated by tyrosine phosphorylation
Application of nuclear magnetic resonance spectroscopy to the structure determination of the integral membrane proteins of the Mer operon
 
Discovery and description of a novel toxin within the pan-genome of the waterborne pathogen Vibrio cholerae
NF-kappaB RelB/p52 heterodimer: Biogenesis and DNA recognition
 
Co-opting CoA biosynthesis for the in vivo modification of carrier proteins
The function, activation and inhibition of phosphatidic acid phosphohydrolase-1 and Group IVA phospholipase A2 in toll-like receptor-4 activated macrophages
 
Recognition of effectors by the bacterial type III secretion system
Topology, frustration, folding and function of the inflammatory cytokine interleukin-1beta
 
Thermodynamics and the role of allostery in the thrombin-thrombomodulin interaction
Structural investigation and allosteric properties of a unique disulfide bond in C-terminal Src kinase
 
Dissecting centromeric DNA-microtubule interactions in vitro uncovers a mechanism that ensures proper connection of chromosomes to the mitotic spindle
Structures of PKA RII beta holoenzymes define isoform diversity
 
TBP recruitment to the U1 snRNA gene promoter is disrupted by substituting a U6 proximal sequence element A (PSEA) for the U1 PSEA
Lipidomic analysis of eicosanoid dynamics in inflammation and disease
 
On the rough folding landscape of green fluorescent protein
Deuterium exchange mass spectrometry studies of the phospholipase A2 superfamily
 
Bottom up approach for the reconstitution and characterization of DNA replication checkpoint
Reversible phosphorylation in mitochondria
 
The mechanics of SR protein phosphorylation by the splicing kinases SRPK1 and Clk/Sty
Chemoenzymatic investigations of protein-protein interactions in carrier protein-mediated biosynthesis
 
The folding energy landscape of cytochrome c: Theoretical and experimental investigations
Mechanism, function and modulation of oncogenic Cripto signaling
 
P105 and p100 proteins function as the core of heterogeneous NF-kappaB complexes
Development of a large format direct detection device for three dimensional transmission electron microscopy
 
Computational and pharmacological modeling of membrane proteins
Amplified detection of protease activity using porous silicon nanostructures
 
G proteins and their regulators in EGF receptor trafficking and mitochondrial functions
Structure-function relationships in enzymes of the nucleotidyltransferase superfamily: RNA ligation and mRNA capping
 
A NF-kappaB temporal code to ensure specificity in inflammatory signaling
Dissecting the allosteric regulation of PKA-I alpha activation
 
The intersection of NFkappaB and fibroblast growth factor receptor signaling pathways
cAMP-induced allosteric switch in PKA
 
Insights into the homeostatic regulation of I kappa B alpha
Structural characterization of viral capsid maturation in bacteriophage HK97
 
RhoA, B, and C in cancer: Study of statin-induced changes in Rho signaling, and identification of isoform-specific Rho effectors
Distinct functions of negative regulators of NF-kappaB
 
Deciphering proteolytic signaling
Mechanisms that regulate the maturation and down-regulation of protein kinase C
 
Organic synthesis as an effective approach to chemical, pharmaceutical, and biosynthetic investigations of natural products
Biosynthesis of scytonemin, a cyanobacterial sunscreen
 
Spatiotemporal regulation of protein kinase C signaling: Control of normal cellular dynamics and mis-regulation in cancer
Directional phosphorylation and dephosphorylation of the SR protein ASF/SF2
 
Small molecule interactions with heparan sulfate
Cancer, cell fate, and transcription: Regulation of the p53 transcriptional response by structurally diverse core promoters
 
Kinetics of codon recognition on the ribosome by tRNAs and release factors
Methods and devices for fabricating and assembling DNA and protein arrays for high-throughput analyses
 
Throwing a wrench in the translational machinery: Discovery of RNA ligands by fluorescence techniques
Crosslinking studies in natural products biosynthesis
 
Structural studies of bacteriophage Hong Kong 97 prohead I and development of nano-particle applications
Think positively: The structural basis of cation-binding and coupling of the multidrug and toxic-compound extrusion (MATE) transporter family
 
Synthesis and applications of quinazoline-based fluorescent nucleoside analogues
Biosynthesis and engineering of cyclomarin and cyclomarazine: Prenylated, non-ribosomal cyclic peptides of marine actinobacterial origin
 
Spatial and Temporal Dynamics of Marine Natural Products Biosynthesis
Posttranslational Regulation of Caveolin by Small- Ubiquitin-like Modifier (SUMO) Proteins
 
Metal-Directed Protein Self-Assembly
Inter- and Intracellular Dynamics of DNA Methylation
 
The regulation of global deSUMOylation by human SUMO-specific proteases
The Genetic Basis for Adaptation of Escherichia coli to Growth in Minimal Media
 
Boundary lubrication of articular cartilage: Contribution of hyaluronan in health and injury
The Importance of Metal Binding in Metalloprotein Inhibitors
 
Xenotransplantation of Mitochondrial Electron Transfer Enzyme, Ndi1, Treats Myocardial Reperfusion Injury
Expanding the Utility of Proteins as Platforms for Coordination Chemistry
 
The non-canonical NFkappaB pathway modulates inflammatory signaling by the canonical NFkappaB pathway
Exploring Guanidinoglycoside Molecular Transporters
 
Nanoscale Sensing Methodology Via Functional Control of an Ion Channel-Forming Peptide, Gramicidin A
Development of tools for the preparation of genomic libraries for next-generation sequencing
 
Novel Biodiversity of Natural Products-producing Tropical Marine Cyanobacteria
Biosynthetic Investigations of Ansamycin Natural Products from Marine-Derived Actinomycetes
 
Targeting the brain: Identifying and inhibiting harmful protein-amyloid interactions in Alzheimer's disease
Towards an understanding of human alpha-7 nicotinic acetylcholine receptor selectivity: the creation and characterization of a soluble ligand binding domain template
 
Post-translational modifications in intrinsically disordered regions and their contribution to protein-protein interactions
Structural and Functional Study of Virus Protein 'u' from HIV-1 by Nuclear Magnetic Resonance Spectroscopy
 
The Chemistry and Biology of Zoanthamine Alkaloids and Illicium Sesquiterpenes
Structural and functional studies of the Drosophila melanogaster snRNA activating protein complex (DmSNAPc)
 
Fluorescence-based Investigations of the Dynamics and Properties of Cell Penetrating Peptide Cellular Uptake Mechanisms
Causation in Biology: A Biomolecular Systems View
 
In vivo selection and in vivo evolution of a trans-splicing ribozyme
Development and Application of All-Atom Structure-based Models for Studying the Role of Geometry in Biomolecular Folding and Function
 
Biodegradable Porous Silicon Nanomaterials for Imaging and Treatment of Cancer
Enhanced Sampling Development for Accessing Long Time Scale Protein Dynamics
 
Light-Driven Uncoupling of Nitrogenase Catalysis from ATP Hydrolysis
Investigating the Role of Turn Motif and Activation Loop Phosphorylation in the Regulation of PKA Structure and Function
 
Computational Studies in Diffusion and Drug Discovery
The Intricacies of UGT Regulation: Protein-Protein Interactions and Environmental Arsenic Exposure
 
Uncovering Allostery in a Uniquely Folded Metalloprotein