ProQuest Subject Index - Pharmacology at THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

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You are viewing titles for THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL in the Pharmacology available through the UMI Dissertations & Thesis Gradwoorks site

Phase I clinical trial of a chlorhexidine diacetate intraoral delivery system in medically healthy gingivitis subjects	RGS domain-independent Sst2 action

Vascular endothelial cadherin phosphorylation modulates endothelial cell permeability and leukocyte transendothelial migration	CB1 receptor activity modulates responses in the forced swim test and open field test paradigms

Opioid antinociception and antihyperalgesia in combination with metabotropic glutamate receptor antagonism	Identifying genetic factors affecting anthracycline-induced cytotoxicity

Prediction of brain extracellular fluid concentrations: Application to understanding central nervous system pharmacokinetics and pharmacodynamics	Dopamine D2 receptor functional selectivity as a mechanism of atypical antipsychotic drug action

Multiple domain 'nexus' proteins in receptor-mediated cell signaling	Mechanisms of ligand-receptor interactions of the dopamine D2L receptor and their relation to functional selectivity

Agonist-promoted regulation of the P2Y1 receptor: Quantification of native and recombinant receptors with the novel radioligand [32P]MRS2500	Regulation of phospholipase C-epsilon by Rho and Ras family proteins

Accumulation and intracellular distribution of aromatic diamidines in African trypanosomes	Regulation of the transforming immortalized mammary protein and its homologs by auto-inhibition and tyrosine phosphorylation

Clathrin-dependent internalization of protease-activated receptor-1: Regulation by ubiquitination and epsin	CIB1 mediated regulation of endothelial cells and pathological angiogenesis

Development and application of ligand-based and structure-based computational drug discovery tools based on frequent subgraph mining of chemical structures	Cloning and characterization of a novel phospholipase C enzyme, human phospholipase C Eta2

Structural insights into the molecular basis of heterotrimeric G-protein signal transduction	Regulation of human cytidine triphosphate synthetase 1 by phosphorylation and interacting proteins

The regulation of carbamoyl phosphate synthetase-aspartate transcarbamoylase-dihydroorotase (CAD) by phosphorylation and protein-protein interactions	Identification of targeting signals in human P2Y receptors in polarized MDCK(II) epithelial cells

Regulation of cell survival by CIB1, a new modulator of 3-phosphoinositide-dependent protein kinase 1 (PDK1)	Interplay between p-glycoprotein-mediated efflux and cytochrome P4503A-mediated metabolism in the intestine

Aerosol delivery of recombinant antigen 85B in microparticle vaccine systems for protection against tuberculosis	Experimental approaches to measuring brain exposure: Rate, extent and regional distribution

Association between tardive dyskinesia and dopamine receptor genes among patients with chronic schizophrenia	Targeting Ras and Rho family GTPases for the treatment of cancer through inhibition of CAAX-signaled modifications and the ERK MAPK pathway

The role and mechanism of fibroblast growth factor receptor 2 in cellular transformation	Activation of G protein signaling by a non-receptor exchange factor

Design, synthesis, and biological evaluation of betulinic acid derivatives as potent anti-HIV-1 agents	The role of metabotropic glutamate receptors and associated cell signaling pathways in the acute sedative-hypnotic effects of ethanol

Antimicrobial and wound healing properties of nitric oxide-releasing xerogels and silica nanoparticles	A multi-factorial approach to understanding and predicting brain exposure to pharmacologic agents

Structural basis for ligand-binding and activation of D1-like dopamine receptors	Regulation and function of the cerebral cavernous malformation 2 protein

Molecular pharmacology and function of the P2Y14 receptor	Investigating the mechanism of ethanol-enhanced GABA release

GABA suppresses thermal and mechanical sensitivity of mouse cutaneous afferent fibers	Mechanisms of ethanol-induced steroidogenesis following acute and chronic ethanol exposure

Design, synthesis, and biological evaluation of novel neo-tanshinlactone analogues as potent and selective anti-breast cancer agents	Delineating and rationally perturbing signaling mechanisms involved in metastasis

An investigation into the role of glucuronidation on the disposition and toxicity of mycophenolic acid using targeted quantitative proteomics	Disposition of mycophenolic acid and its glucuronide metabolites in subjects with glomerulonephritis: Implications of genes and effects on kidney outcomes

Identification of novel therapeutic approaches and targets for the treatment of ovarian carcinoma	The effect of the dynamic interplay of P-glycoprotein and cytochrome P450 3A on the portal bioavailability of dual substrates

Molecular adaptation to anti-cancer chemotherapy in leukemia	Coordination of map kinase signaling during cell fate decisions

Mechanisms of mu opioid receptor mediated protection from multiple models of acute injury	Characterization of the breast cancer kinome