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You are viewing titles for THE SCRIPPS RESEARCH INSTITUTE in the Biochemistry available through the UMI Dissertations & Thesis Gradwoorks site
 
Chapter 1. Synthesis and Evaluation of a Series of C5'-Substituted Duocarmycin SA Analogs; Chapter 2. Progress Towards the Synthesis and Biological Characterization of a Novel Symmetric DNA Bis-Alkylating Agent; Chapter 3. Selected Cytoxicity Studies
Early Evaluation of Natural Products as Antibiotics and Chemical Biology Probes
 
Three functional genomic approaches to biochemical and screen-based analyses of topics in cellular biology
Pathological consequences of tRNA synthetase induced mistranslation
 
Part I. A small-molecule library strategy for disruption of protein-protein interactions. Part II. Antibody-catalyzed anaerobic destruction of methamphetamine: A new direction in immunopharmacotherapy. Part III. Design and synthesis of reactive immunization haptens
Yeast and phage display of antibodies: Comparisons and new developments
 
Enzyme discovery and characterization by proteome reactivity profiling
Exploring glycan function. I. Intrinsic effects of N-glycans on beta-sheet protein folding. II. Development of glycoproteomic tools for monitoring glycan transformations
 
Applications of polyvalent carbohydrate display on Cowpea Mosaic Virus and bacteriophage Qbeta
Development of icosahedral virus particles as multivalent display scaffolds for metal complexes
 
Characterization of a role for the serine hydrolase enzyme KIAA1363 in cancer biology using functional proteomics and metabolomics
Part I. Chemistry and biology of uncialamycin. Part II. Total synthesis of aspidophytine
 
Applications of an expanded genetic code
Self-sustained replication of an RNA enzyme
 
Continuous in vitro evolution of competing ligase ribozymes
Defining the mechanisms and regulation of dynamin's GTPase activities
 
Synthetic and endogenous small molecules that regulate stem cell fate
Expanding the scope of the enzymatic synthesis of DNA for (i) expansion of the genetic alphabet and (ii) next generation sequencing
 
Structure and energetics of amyloid
Analysis of E. coli 30S ribosomal subunit assembly kinetics by quantitative mass spectrometry
 
Structural diversity of the NTF2-like fold drives functional versatility in the NXF family and beyond
Small molecules, regeneration, and cell fate
 
Insight into the reprogramming of cell fate with small molecules
Protein engineering with natural and unnatural amino acids
 
Visualizing biological complexity: Toward discovery based single particle electron microscopy
RNA-mediated transcriptional regulation in human cells: Mechanistic insights and novel effector molecules
 
Expanding the genetic lexicon
Copper-Catalyzed Alkyne-Azide Cycloaddition and Thiol-Oxanobornadiene Reactions for Bioconjugation
 
Enhanced Aromatic Sequons in Turns Reliably Stabilize N-linked Glycoprotein Native States
Biochemical and Structural Characterization of Non-Specific RNA-Binding Zinc Finger Proteins
 
Functional studies of aminoacyl-tRNA synthetases in translation and beyond
Orchestration of Molecular Information through Higher Order Chemical Recognition
 
Development and Application of Activity-Based Proteomic Platforms for Inhibitor Discovery
Genetic and Chemical Approaches to Understanding S1P1 Receptor Physiology and Pathology
 
I. Synthesis and Biological Evaluation of Bridged Nucleosides and BE-43472B Analogues II. Progress Towards the Total Synthesis and Structural Determination of Brasiliensophyllic Acid A
Annotation of Serine Hydrolase Function in Mammalian Physiology and Behavior
 
Probing the Molecular Pathogenesis of Gelsolin Amyloidosis
Annotation of Serine Hydrolase Function in Mammalian Physiology and Behavior
 
Development and Application of Advanced Proteomic Methods to Globally Map Protease Substrate Profiles
Fusion Protein Partners for the Stabilization and Crystallization of G protein-Coupled Receptors
 
Synthesis of Antibody Conjugates using an Expanded Genetic Code
Promoting Protein Folding with N-glycosylation and Amyloid Disaggregation
 
Modulating the immune response: Part I: Biochemical activation of PAD4 and function in autoimmune disease Part II: Phage display tools for the study of protein-protein interactions in the immune system
Small Molecules Modulating Hematopoietic Stem Cell Differentiation
 
Intracellular studies of ribozymes and riboswitches