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You are viewing titles for THE JOHNS HOPKINS UNIVERSITY in the Pharmacology subject available through the ProQuest Dissertations & Theses Gradworks site.


An investigation of protein kinase mechanism using bisubstrate analog inhibitors An optimized optokinetic behavioral assay to assess central nervous system function in mice Antiretroviral drug penetration into the male genital tract Applications of protein microarray technology in the study of virus infections and host -virus interactions Characterization of a novel FLT3 inhibitor in acute myeloid leukemia Characterization of the protein -protein interaction between Nef and SRC family kinase SH3 domains is used to develop small molecule compounds Chemistry and biology of human methionine aminopeptidases Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: A randomized controlled trial Development and application of a reporter-probe system based on the Prostate Specific Membrane Antigen Development of inhibitors against the SARS coronaviral protease 3CLpro Elucidating the mechanisms of EBV lytic gene expression and cytotoxicity by protease inhibition Establishing candidate biomarkers to determine the pharmacodynamic action of sulforaphane in the breast Experimental approaches to rational strategies for the prophylaxis and treatment of falciparum malaria Exploitation of the cancer biomarker alpha methylacyl coenzyme A racemase for cancer imaging and therapeutics Forget the messenger. - kill the translator! On the mechanism of new and old glutarimides Genomic and transcriptomic characterization of breast, colorectal, pancreatic, and brain cancers as well as anti-tumor agent, C. novyi-NT Identification and characterization of 3-nitrotyrosine modified proteins in cerebrospinal fluid Identification and mechanistic deconvolution of inhibitors of T cell receptor signaling pathway from the Johns Hopkins Drug Library Illuminating kinase signaling dynamics in living cells with optical biosensors Illuminating spatiotemporal regulation of cyclic AMP signaling dynamics in live cells using novel FRET -based biosensors Inhibitory roles of NRF2 and an oleanolic triterpenoid on adipocyte differentiation and obesity Intracellular delivery of diphosphate analogs: Design, synthesis, and evaluation of bisphosphonamidate prodrugs Investigating novel immunomodulatory roles of prostate-specific antigen Investigating the uptake of radiolabeled FIAU and the role of EBV kinases in enzyme-targeted radionuclide therapy Investigation of the catalytic mechanisms of CarB and CPS, the first two essential enzymes in the biosynthetic pathway of (5R)-carbapen-2-em-3-carboxylic acid Mechanism of action of the antiproliferative natural product triptolide Mechanistic and structural studies on p300 /CBP transcriptional coactivator Mechanistic studies of clinical drugs with unexplained antiangiogenic activity Melanoma-specific gene expression is altered by a hypoxic microenvironment: Implications for therapy and radiosensitivity Methionine aminopeptidases from Mycobacterium tuberculosis as novel anti-tuberculosis targets Muco-inert nanoparticle probes and drug carriers Pharmacological interactions between natural health products and antiretrovirals: Role of phase 2 enzyme induction Polymer-based approaches for the therapy of prostate cancer Quantitation of human immunodeficiency virus (HIV) surrogate and tenofovir distribution in the gastrointestinal and female genital tracts Regulation of protein kinase CK2 through posttranslational modifications Regulation of transcriptional plasticity by GAPDH and IPMK Reversing HIV-1 latency using small molecules Sialidase enhances anatomical and functional recovery from spinal cord contusion injury Studies on chemoprotection by sulforaphane Targeting Nrf2 signaling for cancer chemoprevention using synthetic triterpenoids Targeting carcinoma-associated fibroblasts (CAFs) with a fibroblast activation protein (FAP)-activated prodrug chemotherapy Targeting epigenetic repression by interfering with methyl -binding domain protein function Targeting the topoisomerases of African trypanosomes and malaria parasites with topoisomerase poisons The effect of protein binding on antiretroviral drug distribution and antiviral effect among diverse anatomic compartments The rational design of peptidyl based inhibitors of prostate-specific antigen The role of NRF2 on VEGFA/VEGFR expression, hepatic vascularization and cancer growth The role of Nogo-receptor and gangliosides in myelin-associated glycoprotein-mediated axonal regeneration and protection The thioredoxin system and redox regulation of nuclear factor-kappa B signaling The use of polyamidoamine (PAMAM) dendrimers as a method of drug delivery for ligands to G protein-coupled receptors (GPCRS) Two approaches to drug discovery Uracil base excision repair as a therapeutic target Visualizing signal transduction: Revealing the molecular mechanisms of cAMP signaling specificity Vitamin D analogs as cancer preventive agents: Mechanisms of efficacy and toxicity Vitamin D supplementation in pregnant and non-pregnant women in Dhaka, Bangladesh: Pharmacokinetic and safety studies c-Src Chemical Rescue: Contribution to the c-Src Phosphoproteome and the Elucidation of the Mechanism of Activation of C3G