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You are viewing titles for THE JOHNS HOPKINS UNIVERSITY in the Molecular biology subject available through the ProQuest Dissertations & Theses Gradworks site.


3' untranslated regions are the primary regulators of gene expression in the C. elegans germline A PGC-1 alpha:O-GlcNAc transferase complex regulates the transcription factor FoxO in response to glucose A cell-free reconstitution of major histocampatibility complex class II antigen processing A conserved response to diverse small molecules: Implications for therapy A mechanistic study of peptide bond formation and peptide release on the ribosome A novel internal binding motif in the CFTR C-terminus enhances EBP50 multimerization and facilitates endocytic recycling A protein microarray based approach to discovering novel signaling pathways contributing to cancer and viral pathogenesis A role for insulator proteins in gene bookmarking A single nucleotide polymorphism in the CCL2 promoter: Contributions to transcriptional regulation and disease progression A survey of human genetic variation reveals a basis for Sturge-Weber syndrome and non-syndromic port-wine stain A tale of two ABC transporters: Understanding the trafficking of CFTR and ABCG2 Accelerated atherosclerosis in mice lacking Stat3-beta, a global suppressor of systemic inflammation An RNA element that stabilizes translation termination in Rous sarcoma virus Analysis of changes in genome structure by homologous recombination Analysis of heritable silencing induced by dsRNA Antisense RNA cleavers that target the HIV-1 Rev response element Applications of protein microarray technology in the study of virus infections and host -virus interactions Arc mediates homeostatic synaptic scaling of AMPA receptors via its interaction with the endocytic machinery Assembly and function of the Saccharomyces cerevisiae Ctf19 kinetochore subcomplex Bardet-Biedl syndrome and olfaction: Illuminating cilia and sensory neuron biology in a model of human-ciliopathy Binding and dynamic studies of the human ubiquitin conjugating enzyme UBE2G2 by nuclear magnetic resonance spectroscopy Biochemical characterization of ribosomal states involved in decoding and translocation Bioinformatics Approaches to Genetic Abnormality Detection in Genomic Data CARD11 scaffolding activity governs NF-Kappa B activation in immunity an lymphoma Cellular and molecular changes in the development of prostatic hyperplasia in aging Brown Norway rats Cellular targets of the adenovirus E4 oncoproteins Characterization and targeting of oncogenic PIK3CA signaling Characterization of DANGER and its functional interaction with the death-associated protein kinase Characterization of EF-G-dependent translocation in Bacillus stearothermophilus Characterization of double-strand break-induced cohesin domain assembly and function Characterization of the MTERT-deficient mouse and in vivo rescue of short telomere phenotypes Characterization of the ezrin-Chloride Intracellular Channel 4 interaction Characterization of the trans and cis presentation functions of IL -15 receptor alpha on tumor cells and T cells Characterization of vaccinia virus entry-fusion proteins A28 and H2 Cloning and characterization of two novel Taenia solium antigenic proteins and applicability to the diagnosis and control of taeniasis/cysticercosis Construction and characterization of the partially synthetic yeasts Saccharomyces cerevisiae synIXR and semi-synVIL Coordinated Assembly of the Streptococcus pneumoniae single-stranded DNA-binding protein A and single-stranded DNA-binding protein B on single-stranded DNA Creation of a genetically encoded band-pass filter for enzyme activity and its application to combinatorial protein engineering Cullin 5 E3 ubiquitin ligase: Viral and cellular functions DISC1 and Neuregulin-1/ErbB4 signaling in the developing and mature brain Deciphering the role of chromatin and Dnmt1 in maintaining DNA methylation and tumor suppressor gene silencing Degradation of cAMP and regulation of adenylyl cyclase activity controls group migration and signal relay in the social amoebae Dictyostelium discoideum Degradation signals for ubiquitin/proteasome-mediated cytosolic protein quality control Denervation atrophy is indepedent from AKT and mTOR activation and responds differently than disuse atrophy to myostatin inhibition Design rules for protein switch construction and the creation of periplasmic binding protein-beta-lactamase switches Development of new bioanalysis techniques based on confocal fluorescence spectroscopy and nanotechnology for nucleic acid research Direct cardiac reprogramming Discovery of isoform-selective inhibitors of human methionine aminopeptidase 1 and characterization of functional impact of N-terminal methionine excision Dissecting cell fate decisions in human embryonic stem cells Dissection of TnsC reveals domains responsible for Tn7 transposition activation and regulation Distortion-dependent repair of interstrand cross-links Diverse functions of human APOBEC3H genetic variants and novel functions of viral protein Vif in association with RUNX/CBFbeta complex Dynamic regulation of microRNAs by post-transcriptional mechanisms Dynamic regulation of stereocilia length by unconventional myosins and their actin-regulatory cargo Effect of mitochondrial iron on manganese superoxide dismutase Effects of cross-link structure on replication-independent DNA interstrand cross-link repair in mammalian cells Electrostatics of the DNA binding domain of interferon regulatory factor 1 Emergence and fading of HIV drug resistance after single dose nevirapine for prevention of mother -to -child transmission Epigenetic regulation by MYC: Oncogene-mediated changes in H3K27ME3 in prostate cancer Epigenetic silencing of endogenous angiogenesis inhibitors in melanoma Establishing candidate biomarkers to determine the pharmacodynamic action of sulforaphane in the breast Examination of putative flagellar genes in Plasmodium Exploitation of the cancer biomarker alpha methylacyl coenzyme A racemase for cancer imaging and therapeutics Exploring the mechanism of fidelity of translation termination and translation in neurons Expression patterns and regulation of a Candida glabrata adhesin, EPA6 Extracellular adenosine and the adenosine A2A receptor promote T cell tolerance and regulatory T cells Fatty acid metabolism in the zebrafish: The role of acyl-CoA synthetases during embryonic development Formation and maintenance of epithelial tubes: From mechanics to cell death From cancer genetics to noninvasive molecular diagnostics Function and regulation of calcium and manganese homeostasis and signaling by secretory pathway calcium-ATPases Functional and molecular characterization of a primitive bone marrow -derived stem cell Functional and structural studies of the TY1 retrotransposon in Saccharomyces cerevisiae Functional dissection of the essential nucleosome acetyltransferase of H4 (NuA4) complex with genomics and proteomics approaches Functional evaluation of noncoding regulatory control provides novel insights into their constraint, distribution, and overlapping functions Functional studies of rare CFTR missense mutations facilitate interpretation of genotype-phenotype relationships Functionally significant elements in the 3'UTR of human alpha-synuclein Genetic analysis of early gonad formation in Drosophila embryos Genetic and biochemical characterization of the Tsc-Rheb-TOR signaling pathway in Drosophila Genetic and biochemical evidence for a non-transcriptional role of TFII-I: Negative regulator of agonist-induced calcium entry Genetic and functional dissection of the mechanisms of ciliogenesis Genetic heterogeneity in cystic fibrosis Genetics of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD /C) Global assessment of melanoma-endothelial cell communication identifies neuropilin -2 as a mediator of melanoma cell proliferation Glutathione S-transferase pi expression and function in liver Glycomic approaches to study post-translational modification by O-linked beta-N-acetylglucosamine (O-GlcNAc) HIV-1 gp120: A novel, large-scale purification technique and thermodynamic characterization of the binding of two small -molecule inhibitors Histone acetyltransferase p300/CBP as a functionally significant target in melanoma Histone cross-talk during transcription elongation in Drosophila melanogaster Id1 promotes the oncogenic phenotype in melanoma and breast cancer Identification and characteritzation of non-coding RNA in mycobacterium tuberculosis Identification and characterization of neural progenitors in the mammalian hypothalamus Identification and loss-of-function analysis of regulatory elements controlling the initiation and maintenance of ptf1a expression in the pancreas and inhibitory neurons Identification of RNA polymerase II terminator elements and their interaction with the yeast RNA -binding proteins Nrd1 and Nab3 Identification of a Golgi targeting signal in the cytoplasmic tail of the severe acute respiratory syndrome coronavirus envelope protein Identification of a novel polarity regulator at the lagging edge of migrating Dictyostelium cells Identification of a truncating mutation in HDAC2 and its role in regulating apoptotic response to HDACi Identification of transcription factors that direct dopaminergic neuron development through the regulation of NURR1 expression Implication of Huntington phosphorylation in Huntington's Disease pathogenesis Inhibition of long interspersed nuclear elements (LINE) by APOBEC3 proteins Innate immune responses to SIV infection: IFN -beta as an important factor in control of early SIV replication in the CNS Inositol hexakisphosphate kinase-2: Novel modes of regulation and signaling Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB Insights into mammalian sperm -egg adhesion and fusion from studies of knockout mouse models of male infertility Insights into the molecular mechanics of messenger RNA recruitment to the eukaryotic ribosome Insights into the regulation of O-GlcNAc transferase and protein GlcNAcylation Insulator proteins: Regulators of chromatin organization and gene expression in Drosophila melanogaster Integration of embryonic stem cell differentiation and genomics in the identification of novel cardiac genes Interactions between receptor tyrosine kinases in cellular membranes: Physical principles and applications Investigation for Alzheimer's disease susceptibility genes Kinase and phosphatase mutations in leukemia Late steps in 30S ribosome assembly in vivo Ligand specificity of Candida glabrata adhesins Ligase IV/XRCC4 complex: Binding, dissociation, and degradation by adenoviral proteins E4-34K and E1B55K Loss of 3,3-transpeptidases alters the cellular physiology of Mycobacterium tuberculosis Maintenance of nuclear morphology in the yeast, Saccharomyces cerevisiae Manipulating the eukaryotic genomes Mechanism of action of the antiproliferative natural product triptolide Mechanisms of transcriptional regulation in the Hippo signaling pathway Melanoma-specific gene expression is altered by a hypoxic microenvironment: Implications for therapy and radiosensitivity Metamorphosis of Plasmodium sporozoites into exoerythrocytic forms: Discovery of novel degradative pathways in the malaria parasite Methionine aminopeptidases from Mycobacterium tuberculosis as novel anti-tuberculosis targets MicroRNA expression and PASG/LSH deficiency Mitochondrial fatty acid synthesis and its contribution to trypanosome metabolism Mitochondrial regulation of Leydig cell steroid synthesis. Implications for the decline in male testosterone production with advancing age Modification and nuclear organization of the Drosophila melanogaster genome Molecular analysis of LMNA mutations in progeria and related premature aging diseases Molecular and behavioral coding of temperature sensation in Drosophila larvae Molecular determinants of pKa values of internal ionizable groups in proteins: Interactions of internal ionizable groups with surface charges Molecular genetics of Drosophila visual transduction Molecular pathways linked to altered fatty acid metabolism in cancer cells Molecular regulation of neural stem cells and activity-dependent neurogenesis in the adult brain Multiple calcium signaling pathways regulate yeast cell death during the response to mating pheromones Multiple, independent regulatory mechanisms ensure success in Bordetella pertussis pathogenesis Mycobacterial genes required for establishment of central nervous system tuberculosis NAC1, an actin-binding BTB/POZ protein in cancer cell cytokinesis and murine vertebral patterning Nevirapine resistance in HIV-infected women and infants after exposure to nevirapine-based prophylaxis Non-associating heterodimeric DNA methyltransferases as a platform for developing designer methyltransferases Non-canonical TGF-beta signaling in the pathogenesis of Marfan syndrome Non-canonical expression and post-transcriptional regulation of vitellogenin genes in mosquitoes Notch Signaling in Brain Development and Cancer Novel mechanisms of genomic imprinting disruptions in Beckwith -Wiedemann syndrome Novel proteins and novel functions: Probing the unusual mitochondrial biology of trypanosomes Novel therapeutic agents for prostate cancer treatment: Design of bulky anti-androgens, thapsigargin analogs and inhibitors for prostate specific antigen Novel transmitters: D-serine and hydrogen sulfide: Regulation and function Novel viral and cellular functions of the E3 ubiquitin ligases: Cullin 4 and Cullin 5 Nutrient and hormonal control of the protein deacetylase SIRT1 Oxygen sensing and hypoxic gene regulation in fission yeast Oxygen sensing and regulation of sterol homeostasis in fission yeast and mammals Oxygen-dependent regulation of SREBP in fission yeast Persistence of HIV-1 despite highly active antiretroviral therapy (HAART) and immune responses: Evidence for a novel viral reservoir in patients on HAART and characterization of HIV-1 virus and immune responses in elite suppressors Phosphorylation of Parkinson's disease associated leucine-rich repeat kinase 2 (LRRK2) protein Development and Characterization of specific anti-LRRK2 antibodies Probing the multifaceted functions of the Saccharomyces cerevisiae nucleosome through histone mutagenesis Processing of GPI-anchored cell wall proteins in Saccharomyces cerevisiae and a role for DCW1 Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies Protein quality control in the endoplasmic reticulum and cytosol Reactivation of epigenetically silenced retinoic acid receptor-beta for therapy of breast cancer---From molecular mechanism to potential clinical applications Regulation of MBK-2/DYRK during the oocyte-to-embryo transition Regulation of TERT by an antisense RNA and its encoded protein product Regulation of immune function by the A2A adenosine receptor Regulation of musculoskeletal development and function by myostatin/GDF-11 binding proteins Regulation of ribosome function by O-GlcNAcylation Regulation of sexual dimorphism in the Drosophila melanogaster gonad Regulation of the Fps1 glycerol channel in Saccharomyces cerevisiae Regulation of the Hif-1 transcription factor by interacting proteins Regulation of the biosynthesis of glycosylphosphatidyl inositol anchors in Saccharomyces cerevisiae by the small G-protein Ras2 Regulation of the simian immunodeficiency virus long terminal repeat by C/EBP beta and IFN beta-mediated innate immune responses in vitro and in vivo Regulation of ubiquitin conjugation and removal Requirement for TRPgamma for normal feeding behavior Retinoic acid signaling in the development of spinal motor neurons Role of ROS in ischemia-induced angiogenesis Role of the LRS nucleosome surface in telomeric silencing Role of the Translin/Trax complex in RNA processing Roles for transcription and DNA repair in generating genome instability Self -organization of keratin intermediate filaments into crosslinked networks Serendipitous discovery of an allosteric zinc binding site in an engineered protein Single molecule analysis of circulating nucleic acid biomarkers for noninvasive cancer diagnostics Small molecule induction of the stress proteome and its therapeutic potential Sre1 is a hypoxic transcription factor required for virulence in the pathogenic fungus Cryptococcus neoformans Stability and DNA-binding ability of the bZIP dimers formed by the ATF-2 and c-Jun transcription factors Structural and biochemical characterization of components of the fungal GPI transamidase Structural and biophysical characterization of RNA recognition by arginine-serine rich (RS) domains in splice site regulation Structural and functional analysis of dynactin's pointed end complex Study of retrotransposons using high throughput technologies Study of risk genes for schizophrenia in neural development Targeting carcinoma-associated fibroblasts (CAFs) with a fibroblast activation protein (FAP)-activated prodrug chemotherapy Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITD acute myeloid leukemia The Drosophila SF-1-like nuclear hormone receptor Hr39 is essential for female reproductive tract development and function The OAZ transcription factor regulates olfactory receptor neuron development and CNS midline formation The RNAi pathway regulates telomeric repeat-containing RNA in Caenorhabditis elegans The activation and inhibition of mammalian DNA methyltransferases: Studies with nitric oxide and procainamide The association of polycystin -1 with apical -basolateral and planar cell polarity complex and its biological implications The calcium signaling pathway, endoplasmic reticulum stress, and programmed cell death in the yeast Saccharomyces cerevisiae The clonogenic and molecular consequences of genomic demethylation in acute myeloid leukemia cell lines The copper chaperone as a dual regulator of effects related to oxidative stress and chromatin remodeling The effects of adhesion on Kaiso-mediated transcriptional regulation of the MTA family in mammary epithelial cells The effects of insecticide-treated bed net introduction on anopheline and culicine mosquito behavior and insecticide resistance in southern Zambia The end of the beginning: Eukaryotic ribosomal subunit joining and the combined roles of initiation factors 5B and 1A The genomic landscapes of human cancer The human gut microbiota: New analyses and methods on the continuum between disease and health The immune-modulating role of scavenger receptor A (Sra) during inflammation and sepsis The immunomodulatory and anti-HIV effects of minocycline in human CD4+ T cells The integrated genomic analyses of human cancers The interferon beta response to simian immunodeficiency virus infection of the central nervous system: Induction, regulation, and effects The migration and invasion of prostate fibroblasts: A potential contributor to prostate cancer metastasis The novel role of microRNA in pattern formation in the Drosophila ovary The physical-chemical basis behind FGFR activation: Implications for human pathologies The role of Arabidopsis dicers in maintaining DNA methylation The role of Kruppel -like factor four in hematopoiesis The role of Nogo-receptor and gangliosides in myelin-associated glycoprotein-mediated axonal regeneration and protection The role of Tristetraprolin (TTP) in hematopoiesis and homeostasis The role of microRNA and disease-state hematopoiesis The role of mutant KRAS and PIK3CA in human breast cancer tumorigenesis The role of nerve growth factor in axon growth and final target innervation The role of neurotrophin-dependent gene expression in the developing somatosensory nervous system The role of spermine oxidase in inflammation-associated carcinogenesis The roles of the methylcitrate cycle and nicotinamide adenine dinucleotide starvation in Candida glabrata virulence Timing of maternal HIV infection: Association with HIV mother-to-child transmission and clinical outcome Tools for cancer drug discovery Transcriptional regulation of the myelin basic protein gene in zebrafish Transmembrane helix dimerization in lipid bilayers and mammalian membranes Transmembrane semaphorin control of neural circuit assembly in the mammalian retina Tsunami is required for directional responses of Dictyostelium in chemotactic gradients during development UBBplus1 mediated inhibition of the ubiquitin -proteasome system UCH-L1 and cystic fibrosis: A novel role for the deubiquitinating enzyme in CFTR biogenesis Understanding CD4+ T cell dynamics in HIV-1 infection Understanding the role of androgen receptor signaling in breast cancer Unraveling the pathogenic mechanisms underlying myocarditis and dilated cardiomyopathy Uracil DNA glycosylase uses DNA hopping and short -range sliding to trap transient extrahelical uracils Using capture compounds to identify novel S-Adenosylhomocysteine binding proteins Variations on a theme: Transcriptional regulation mediated through post-translational modification and microRNA function Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex c-Src Chemical Rescue: Contribution to the c-Src Phosphoproteome and the Elucidation of the Mechanism of Activation of C3G mTOR controls mitochondrial function through the YY1 transcriptional complex nNos localization, muscle function and atrophy in skeletal muscle disorders