ProQuest Subject Index - Molecular biology at THE JOHNS HOPKINS UNIVERSITY

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You are viewing titles for THE JOHNS HOPKINS UNIVERSITY in the Molecular biology available through the UMI Dissertations & Thesis Gradwoorks site

Mitochondrial fatty acid synthesis and its contribution to trypanosome metabolism	Persistence of HIV-1 despite highly active antiretroviral therapy (HAART) and immune responses: Evidence for a novel viral reservoir in patients on HAART and characterization of HIV-1 virus and immune responses in elite suppressors

Genetic and biochemical evidence for a non-transcriptional role of TFII-I: Negative regulator of agonist-induced calcium entry	Identification of RNA polymerase II terminator elements and their interaction with the yeast RNA-binding proteins Nrd1 and Nab3

The OAZ transcription factor regulates olfactory receptor neuron development and CNS midline formation	The activation and inhibition of mammalian DNA methyltransferases: Studies with nitric oxide and procainamide

Novel mechanisms of genomic imprinting disruptions in Beckwith-Wiedemann syndrome	Tsunami is required for directional responses of Dictyostelium in chemotactic gradients during development

A novel internal binding motif in the CFTR C-terminus enhances EBP50 multimerization and facilitates endocytic recycling	A cell-free reconstitution of major histocampatibility complex class II antigen processing

Analysis of heritable silencing induced by dsRNA	The role of Kruppel-like factor four in hematopoiesis

The Drosophila SF-1-like nuclear hormone receptor Hr39 is essential for female reproductive tract development and function	Id1 promotes the oncogenic phenotype in melanoma and breast cancer

The calcium signaling pathway, endoplasmic reticulum stress, and programmed cell death in the yeast Saccharomyces cerevisiae	Methionine aminopeptidases from Mycobacterium tuberculosis as novel anti-tuberculosis targets

Biochemical characterization of ribosomal states involved in decoding and translocation	Arc mediates homeostatic synaptic scaling of AMPA receptors via its interaction with the endocytic machinery

Novel therapeutic agents for prostate cancer treatment: Design of bulky anti-androgens, thapsigargin analogs and inhibitors for prostate specific antigen	Characterization of double-strand break-induced cohesin domain assembly and function

An RNA element that stabilizes translation termination in Rous sarcoma virus	Manipulating the eukaryotic genomes

A mechanistic study of peptide bond formation and peptide release on the ribosome	Examination of putative flagellar genes in Plasmodium

Identification of transcription factors that direct dopaminergic neuron development through the regulation of NURR1 expression	Expression patterns and regulation of a Candida glabrata adhesin, EPA6

Innate immune responses to SIV infection: IFN-beta as an important factor in control of early SIV replication in the CNS	Cullin 5 E3 ubiquitin ligase: Viral and cellular functions

Emergence and fading of HIV drug resistance after single dose nevirapine for prevention of mother-to-child transmission	Electrostatics of the DNA binding domain of interferon regulatory factor 1

Oxygen sensing and regulation of sterol homeostasis in fission yeast and mammals	Oxygen sensing and hypoxic gene regulation in fission yeast

Probing the multifaceted functions of the Saccharomyces cerevisiae nucleosome through histone mutagenesis	Functional and molecular characterization of a primitive bone marrow-derived stem cell

Serendipitous discovery of an allosteric zinc binding site in an engineered protein	The role of Nogo-receptor and gangliosides in myelin-associated glycoprotein-mediated axonal regeneration and protection

Antisense RNA cleavers that target the HIV-1 Rev response element	Genetic heterogeneity in cystic fibrosis

Novel viral and cellular functions of the E3 ubiquitin ligases: Cullin 4 and Cullin 5	Glutathione S-transferase pi expression and function in liver

Molecular genetics of Drosophila visual transduction	Kinase and phosphatase mutations in leukemia

Development of new bioanalysis techniques based on confocal fluorescence spectroscopy and nanotechnology for nucleic acid research	Extracellular adenosine and the adenosine A2A receptor promote T cell tolerance and regulatory T cells

The association of polycystin-1 with apical-basolateral and planar cell polarity complex and its biological implications	Genetics of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C)

The end of the beginning: Eukaryotic ribosomal subunit joining and the combined roles of initiation factors 5B and 1A	Dissecting cell fate decisions in human embryonic stem cells

Global assessment of melanoma-endothelial cell communication identifies neuropilin-2 as a mediator of melanoma cell proliferation	Functional studies of rare CFTR missense mutations facilitate interpretation of genotype-phenotype relationships

Molecular pathways linked to altered fatty acid metabolism in cancer cells	Functional dissection of the essential nucleosome acetyltransferase of H4 (NuA4) complex with genomics and proteomics approaches

Histone cross-talk during transcription elongation in Drosophila melanogaster	Characterization of EF-G-dependent translocation in Bacillus stearothermophilus

The copper chaperone as a dual regulator of effects related to oxidative stress and chromatin remodeling	Cloning and characterization of two novel Taenia solium antigenic proteins and applicability to the diagnosis and control of taeniasis/cysticercosis

Integration of embryonic stem cell differentiation and genomics in the identification of novel cardiac genes	Characterization of vaccinia virus entry-fusion proteins A28 and H2

Characterization of the trans and cis presentation functions of IL-15 receptor alpha on tumor cells and T cells	Glycomic approaches to study post-translational modification by O-linked beta-N-acetylglucosamine (O-GlcNAc)

Multiple calcium signaling pathways regulate yeast cell death during the response to mating pheromones	Genetic and biochemical characterization of the Tsc-Rheb-TOR signaling pathway in Drosophila

Novel proteins and novel functions: Probing the unusual mitochondrial biology of trypanosomes	Regulation of MBK-2/DYRK during the oocyte-to-embryo transition

Insights into the regulation of O-GlcNAc transferase and protein GlcNAcylation	Identification of a truncating mutation in HDAC2 and its role in regulating apoptotic response to HDACi

Non-canonical TGF-beta signaling in the pathogenesis of Marfan syndrome	Metamorphosis of Plasmodium sporozoites into exoerythrocytic forms: Discovery of novel degradative pathways in the malaria parasite

HIV-1 gp120: A novel, large-scale purification technique and thermodynamic characterization of the binding of two small-molecule inhibitors	Molecular regulation of neural stem cells and activity-dependent neurogenesis in the adult brain

Protein quality control in the endoplasmic reticulum and cytosol	Mitochondrial regulation of Leydig cell steroid synthesis. Implications for the decline in male testosterone production with advancing age

Role of the LRS nucleosome surface in telomeric silencing	Uracil DNA glycosylase uses DNA hopping and short-range sliding to trap transient extrahelical uracils

Understanding CD4+ T cell dynamics in HIV-1 infection	Melanoma-specific gene expression is altered by a hypoxic microenvironment: Implications for therapy and radiosensitivity

The role of neurotrophin-dependent gene expression in the developing somatosensory nervous system	The genomic landscapes of human cancer

Cellular and molecular changes in the development of prostatic hyperplasia in aging Brown Norway rats	Retinoic acid signaling in the development of spinal motor neurons

Characterization and targeting of oncogenic PIK3CA signaling	Epigenetic silencing of endogenous angiogenesis inhibitors in melanoma

Dynamic regulation of microRNAs by post-transcriptional mechanisms	Tools for cancer drug discovery

Ligand specificity of Candida glabrata adhesins	A PGC-1 alpha:O-GlcNAc transferase complex regulates the transcription factor FoxO in response to glucose

Formation and maintenance of epithelial tubes: From mechanics to cell death	Structural and biophysical characterization of RNA recognition by arginine-serine rich (RS) domains in splice site regulation

Genetic analysis of early gonad formation in Drosophila embryos	Functionally significant elements in the 3'UTR of human alpha-synuclein

Regulation of sexual dimorphism in the Drosophila melanogaster gonad	Effect of mitochondrial iron on manganese superoxide dismutase

Role of ROS in ischemia-induced angiogenesis	Nevirapine resistance in HIV-infected women and infants after exposure to nevirapine-based prophylaxis

mTOR controls mitochondrial function through the YY1 transcriptional complex	Characterization of DANGER and its functional interaction with the death-associated protein kinase

Self-organization of keratin intermediate filaments into crosslinked networks	Inhibition of long interspersed nuclear elements (LINE) by APOBEC3 proteins

Requirement for TRPgamma for normal feeding behavior	UBBplus1 mediated inhibition of the ubiquitin-proteasome system

Applications of protein microarray technology in the study of virus infections and host-virus interactions	The human gut microbiota: New analyses and methods on the continuum between disease and health

Non-associating heterodimeric DNA methyltransferases as a platform for developing designer methyltransferases	Creation of a genetically encoded band-pass filter for enzyme activity and its application to combinatorial protein engineering

Degradation of cAMP and regulation of adenylyl cyclase activity controls group migration and signal relay in the social amoebae Dictyostelium discoideum	Functional evaluation of noncoding regulatory control provides novel insights into their constraint, distribution, and overlapping functions

3' untranslated regions are the primary regulators of gene expression in the C. elegans germline	Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies

Unraveling the pathogenic mechanisms underlying myocarditis and dilated cardiomyopathy	Regulation of the Hif-1 transcription factor by interacting proteins

Interactions between receptor tyrosine kinases in cellular membranes: Physical principles and applications	The interferon beta response to simian immunodeficiency virus infection of the central nervous system: Induction, regulation, and effects

Sre1 is a hypoxic transcription factor required for virulence in the pathogenic fungus Cryptococcus neoformans	Insights into mammalian sperm-egg adhesion and fusion from studies of knockout mouse models of male infertility

Analysis of changes in genome structure by homologous recombination	Binding and dynamic studies of the human ubiquitin conjugating enzyme UBE2G2 by nuclear magnetic resonance spectroscopy

Regulation of the simian immunodeficiency virus long terminal repeat by C/EBP beta and IFN beta-mediated innate immune responses in vitro and in vivo	Cellular targets of the adenovirus E4 oncoproteins

Transcriptional regulation of the myelin basic protein gene in zebrafish	Stability and DNA-binding ability of the bZIP dimers formed by the ATF-2 and c-Jun transcription factors

The role of Arabidopsis dicers in maintaining DNA methylation	The effects of adhesion on Kaiso-mediated transcriptional regulation of the MTA family in mammary epithelial cells

Assembly and function of the Saccharomyces cerevisiae Ctf19 kinetochore subcomplex	Novel transmitters: D-serine and hydrogen sulfide: Regulation and function

The role of Tristetraprolin (TTP) in hematopoiesis and homeostasis	Phosphorylation of Parkinson's disease associated leucine-rich repeat kinase 2 (LRRK2) protein Development and Characterization of specific anti-LRRK2 antibodies

The role of spermine oxidase in inflammation-associated carcinogenesis	UCH-L1 and cystic fibrosis: A novel role for the deubiquitinating enzyme in CFTR biogenesis

Insights into the molecular mechanics of messenger RNA recruitment to the eukaryotic ribosome	The integrated genomic analyses of human cancers

Effects of cross-link structure on replication-independent DNA interstrand cross-link repair in mammalian cells	Distortion-dependent repair of interstrand cross-links

Ligase IV/XRCC4 complex: Binding, dissociation, and degradation by adenoviral proteins E4-34K and E1B55K	Coordinated Assembly of the Streptococcus pneumoniae single-stranded DNA-binding protein A and single-stranded DNA-binding protein B on single-stranded DNA

CARD11 scaffolding activity governs NF-Kappa B activation in immunity an lymphoma	Transmembrane helix dimerization in lipid bilayers and mammalian membranes

Identification of a Golgi targeting signal in the cytoplasmic tail of the severe acute respiratory syndrome coronavirus envelope protein	Deciphering the role of chromatin and Dnmt1 in maintaining DNA methylation and tumor suppressor gene silencing

Regulation of the biosynthesis of glycosylphosphatidyl inositol anchors in Saccharomyces cerevisiae by the small G-protein Ras2	The immunomodulatory and anti-HIV effects of minocycline in human CD4+ T cells

Bardet-Biedl syndrome and olfaction: Illuminating cilia and sensory neuron biology in a model of human-ciliopathy	A single nucleotide polymorphism in the CCL2 promoter: Contributions to transcriptional regulation and disease progression

Transmembrane semaphorin control of neural circuit assembly in the mammalian retina	Dynamic regulation of stereocilia length by unconventional myosins and their actin-regulatory cargo

Characterization of the ezrin-Chloride Intracellular Channel 4 interaction	The novel role of microRNA in pattern formation in the Drosophila ovary

Single molecule analysis of circulating nucleic acid biomarkers for noninvasive cancer diagnostics	Exploitation of the cancer biomarker alpha methylacyl coenzyme A racemase for cancer imaging and therapeutics

Targeting carcinoma-associated fibroblasts (CAFs) with a fibroblast activation protein (FAP)-activated prodrug chemotherapy	Regulation of the Fps1 glycerol channel in Saccharomyces cerevisiae

Mycobacterial genes required for establishment of central nervous system tuberculosis	The effects of insecticide-treated bed net introduction on anopheline and culicine mosquito behavior and insecticide resistance in southern Zambia

A conserved response to diverse small molecules: Implications for therapy	Insulator proteins: Regulators of chromatin organization and gene expression in Drosophila melanogaster

Role of the Translin/Trax complex in RNA processing	Function and regulation of calcium and manganese homeostasis and signaling by secretory pathway calcium-ATPases

Nutrient and hormonal control of the protein deacetylase SIRT1	Understanding the role of androgen receptor signaling in breast cancer

The migration and invasion of prostate fibroblasts: A potential contributor to prostate cancer metastasis	Accelerated atherosclerosis in mice lacking Stat3-beta, a global suppressor of systemic inflammation

Variations on a theme: Transcriptional regulation mediated through post-translational modification and microRNA function	The role of nerve growth factor in axon growth and final target innervation

Maintenance of nuclear morphology in the yeast, Saccharomyces cerevisiae	Multiple, independent regulatory mechanisms ensure success in Bordetella pertussis pathogenesis

Establishing candidate biomarkers to determine the pharmacodynamic action of sulforaphane in the breast	Construction and characterization of the partially synthetic yeasts Saccharomyces cerevisiae synIXR and semi-synVIL

Identification and loss-of-function analysis of regulatory elements controlling the initiation and maintenance of ptf1a expression in the pancreas and inhibitory neurons	DISC1 and Neuregulin-1/ErbB4 signaling in the developing and mature brain

Dissection of TnsC reveals domains responsible for Tn7 transposition activation and regulation	Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex

A protein microarray based approach to discovering novel signaling pathways contributing to cancer and viral pathogenesis	The physical-chemical basis behind FGFR activation: Implications for human pathologies

Small molecule induction of the stress proteome and its therapeutic potential	The RNAi pathway regulates telomeric repeat-containing RNA in Caenorhabditis elegans

Non-canonical expression and post-transcriptional regulation of vitellogenin genes in mosquitoes	Oxygen-dependent regulation of SREBP in fission yeast

Characterization of the MTERT-deficient mouse and in vivo rescue of short telomere phenotypes	The immune-modulating role of scavenger receptor A (Sra) during inflammation and sepsis

Regulation of TERT by an antisense RNA and its encoded protein product	MicroRNA expression and PASG/LSH deficiency

Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB	The role of mutant KRAS and PIK3CA in human breast cancer tumorigenesis

Inositol hexakisphosphate kinase-2: Novel modes of regulation and signaling	Histone acetyltransferase p300/CBP as a functionally significant target in melanoma

Investigation for Alzheimer's disease susceptibility genes	NAC1, an actin-binding BTB/POZ protein in cancer cell cytokinesis and murine vertebral patterning

Mechanism of action of the antiproliferative natural product triptolide	Notch Signaling in Brain Development and Cancer

c-Src Chemical Rescue: Contribution to the c-Src Phosphoproteome and the Elucidation of the Mechanism of Activation of C3G	Study of risk genes for schizophrenia in neural development

Study of retrotransposons using high throughput technologies