ProQuest Subject Index - Biophysics at THE JOHNS HOPKINS UNIVERSITY

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You are viewing titles for THE JOHNS HOPKINS UNIVERSITY in the Biophysics available through the UMI Dissertations & Thesis Gradwoorks site

Binding studies of human ubiquitin conjugating enzyme 7 and the experimental demonstration of residual dipolar coupling methodology by nuclear magnetic resonance spectroscopy	Computational and experimental studies of conformational entropy in proteins and model systems

Characterization of ribosomal proteins L10 and L12 from Bacillus stearothermophilus: Recognition of RNA targets and interaction with EF-G	Predicting coupling limits and folding kinetics from an experimentally-determined folding energy landscape

Vector alignment search tool (VAST) automated protein structure comparison using special structural elements	Structural and energetic consequences of the ionization of internal groups in staphylococcal nuclease

Novel therapeutic agents for prostate cancer treatment: Design of bulky anti-androgens, thapsigargin analogs and inhibitors for prostate specific antigen	Molecular determinants of pKa values of histidine residues in staphylococcal nuclease

Characterization of the folding pathways and cooperativity of repeat proteins via equilibrium, kinetic and forced-unfolding studies	Multiple alignment tensors from a denatured protein

Diffraction studies of fluid lipid bilayers with membrane proteins	Electrostatics of the DNA binding domain of interferon regulatory factor 1

Secondary structure rearrangements in RNA and RNA-protein complexes	Serendipitous discovery of an allosteric zinc binding site in an engineered protein

Probing protein structure and dynamics from residual dipolar couplings measured under multiple aligning conditions	The end of the beginning: Eukaryotic ribosomal subunit joining and the combined roles of initiation factors 5B and 1A

Development of inhibitors against the SARS coronaviral protease 3CLpro	Dimerization of the SARS coronavirus 3CL protease is controlled through long-range interactions

Characterization of the protein-protein interaction between Nef and SRC family kinase SH3 domains is used to develop small molecule compounds	Single molecule biosensing with quantum dots for nanomedicine in diagnostics and therapeutics

Insights into oncogenic PIK3CA mutations from a human PI3K-alpha structure	Determinants of electrostatic energies and pKa values in proteins

Molecular determinants of pKa values of internal ionizable groups in staphylococcal nuclease	Characterization of EF-G-dependent translocation in Bacillus stearothermophilus

Hedgehog proteins require different co-factors to bind vertebrate and invertebrate Ihog homologs	A Residual Dipolar Coupling analysis of methyl containing side chains in ubiquitin

Small angle scatting studies of self assembly in lipid mixtures	A treatise on theoretical and computational mechanobiology in myosin motors and bacterial cell division

Systematic analysis of motions and communication networks in a benchmark set of allosteric proteins	Structural and dynamic consequences of the ionization of internal ionizable groups in staphylococcal nuclease

Applications of magnetic nanostructures to cell patterning and heterotypic cell-cell interactions	Structural insights into Sir2 enzymes

The biophysics of germline determination in the C. elegans early embryo	Determining the general principles that govern membrane protein folding and assembly

Structural and biophysical characterization of RNA recognition by arginine-serine rich (RS) domains in splice site regulation	Measurement of single molecule torque

A computational study of the neural mechanisms for border ownership coding in primate V2	Origins of heterogeneous stability and cooperativity in a large leucine-rich repeat protein, YopM

Probing the dynamics of cellular traction forces with magnetic and non-magnetic micropost arrays	Structure determination and design of biomineral-associated proteins

Studies of the translational entropy contribution to protein stability by use of the HIV-1 protease as a model system	Deconstruction of fungal, nonreducing iterative type I polyketide synthases

Cellular responses to spatial information in the microenvironment	Investigating the role of the initiator tRNA in start codon recognition during eukaryotic translation initiation

NMR study of the rapidly exchanging protons in the catalytic triad of chymotrypsinogen-A	Predicting the structure and function of protein mutants

Interactions between receptor tyrosine kinases in cellular membranes: Physical principles and applications	A multiscale computational investigation of forces between lipid bilayers

Using computational protein docking to model the structure and specificity of protein interactions	Binding and folding of intrinsically disordered regions of proteins: Analysis of recognition elements in hemeproteins and peptides

In vitro investigations of the hemoglobins from the bacteria Synechocystis sp. PCC 6803, Synechococcus sp. PCC 7002, and Helicobacter hepaticus	Binding and dynamic studies of the human ubiquitin conjugating enzyme UBE2G2 by nuclear magnetic resonance spectroscopy

A structural and thermodynamic description of the interaction between deltex and the notch ankyrin domain	Computational antibody structure prediction and antibody-antigen docking

Toward a protein fragment library from physical-chemical first principles	An examination of the mechanisms of allosteric regulation in the oligomeric transcriptional regulators TetR and AraC

Insights into the molecular mechanics of messenger RNA recruitment to the eukaryotic ribosome	The role of helix 69 during tRNA selection on the ribosome

Transmembrane helix dimerization in lipid bilayers and mammalian membranes	Dynamic regulation of stereocilia length by unconventional myosins and their actin-regulatory cargo

Exploring the substrates of Sir2 enzymes	Mechanisms underlying lung injury and inflammation following experimental mechanical ventilation

Structure and function of wild-type and mutant phosphoinositide 3-kinase alpha	Characterizing cytoskeleton-mediated biophysical defects in laminopathic disease models

Design of a biologically relevant, planar lipid bilayer platform for the study of membrane proteins	The role of FIS1 in the recruitment of mitochondrial fission factors and its interaction with membranes

Understanding directed cell migration: From image processing to mathematical modeling	Dynamics in DNA damage detection and repair

Visualizing signal transduction: Revealing the molecular mechanisms of cAMP signaling specificity	Thermodynamics of metal binding to protein sites

Computational models of cell division	Investigations of polyproline II propensity in engineered polypeptides and the proteome

Thermodynamic and transciptional analysis of the CSL switch mechanism in Notch signaling	Single-molecule studies of a stochastic gene regulation by the lambda repressor in live E. coli cells

Characterization of SUMO-modified substrates by mass spectrometry	The effect of protein binding on antiretroviral drug distribution and antiviral effect among diverse anatomic compartments