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Development of new approaches to NMR data collection for protein structure determination
Characterization of beta-arrestin-modulated lipid kinase activities for diacylglycerol and phosphatidylinositol 4-phosphate
 
Protein engineering and design of thermostable biosensors
Ligand interaction and regulation in eukaryotic Hsp90 homologs
 
RNA backbone rotamers and chiropraxis
Structural determinants of post-transcriptional protein regulation as modulators of monoamine signaling
 
The structure and mechanism of GRP94, the endoplasmic reticulum Hsp90 chaperone
Casein kinase I, axin and GSK3-beta regulate Smad3 ubiquitination and Transforming Growth Factor-beta signaling
 
Biophysical characterization of iron siderophores and iron siderophore mimics
Novel mass spectrometry-based strategies for biophysical analysis of proteins and protein-ligand complexes
 
Towards the molecular basis of affinity in monovalent and multivalent protein-carbohydrate interactions
Evolution of vision in coleoid cephalopods
 
Protein engineering for biosensor development
Nitric oxide in health and disease: Physiology, pathophysiology, and clinical measurement
 
Thermodynamic and kinetic analysis of substrate binding in a bacterial transferrin, Ferric Binding Protein A
Inhibition of the zinc-dependent deacetylase LpxC: A structural and kinetic characterization
 
Molecular analyses of melanins and neuromelanins
Exogenous and endogenous chelating agents for mitigating metal-promoted oxidative stress
 
Interactions of the MetJ repressor from E. coli with DNA and SAM
In vivo analysis of the consequences and the repair mechanisms of azacytidine-induced DNA-protein crosslinks
 
Molecular computing with DNA self-assembly
Biophysical investigations of boranophosphate siRNA for use in RNA interference against human disease
 
Pharmacological targeting of the mitochondrial phosphatase PTPMT1
ZFP36L3: A unique member of the tristetraprolin family of RNA-binding CCCH tandem zinc finger proteins
 
Structure-function studies in sulfite oxidase with altered active sites
Kinetic and structural characterization of LpxD, the N-acyltransferase of lipid A biosynthesis
 
Ubiquitin recognition by ubiquitin-binding domains in Y-family DNA polymerases
Regulation of translation by Eukaryotic translation initiation factor 4G
 
Thermodynamic basis of additivity in ligand binding: Matrix metalloproteinase-3
Analysis and error correction in structures of macromolecular interiors and interfaces
 
A covalent modification technique for protein-ligand binding analysis using mass spectrometry-based proteomics platforms
NMR structure improvement: A structural bioinformatics & visualization approach
 
alpha-P-borano ddNTP analogs: Substrate/inhibitory properties for kinases and polymerases and inhibition of wild type and drug resistant HIV replication
Competing RNA Structures and Their Effects on HDV Antigenomic RNA Self cleavage and mRNA Processing
 
Building Better Backbones: Visualizations, Analyses, and Tools for Higher Quality Macromolecular Structure Models
Analysis and redesign of protein-protein interactions: A hotspot-centric view
 
Phosphorylation bar codes induce distinct conformations and functionalities of beta-arrestin
The Role of Galphaz in Neuron Development and CNS Biology
 
Exploring the Immunogenicity and Therapeutic Applications of Boranophosphate-modified RNA: siRNA and RNA Aptamers
Molecular Mechanism of Zipper Interacting Protein Kinase
 
Regulation of CaMKKbeta-Dependent Signaling Pathways
Applications of photoemission electron microscopy to melanin and melanosomes
 
Proteins Inside Cells and On the Surface of Membranes: Developing Three Dimensional In-Cell NMR and Structural Characterization of a Trimeric Membrane Proximal External Region Construct from HIV-1 gp41
Structural and Kinetic Characterization of RNA Polymerase II C-Terminal Domain Phosphatase Ssu72 and Development of New Methods for NMR Studies of Large Proteins
 
Development of RNA Aptamers and Antidotes as Antithrombotic Therapeutics
Mechanisms of Microbial Formation and Photodegradation of Methylmercury in the Aquatic Environment
 
Investigating Alternative Splicing and Polyadenylation of the Interleukin 7 Receptor (IL7R) Exon 6: Implications for Multiple Sclerosis
A Theoretical and Experimental Study of DNA Self-assembly
 
The Evolution of the Deacetylase Sir2 in Yeast
Studies on Adenine Nucleotide States and their Role in Human MutSalphaFunction