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COLUMBIA UNIVERSITY
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The total synthesis of cribrostatin IV and cribrostatin IV analogs
Enantioselective imine cinnamylation: Rapid construction of contiguous benzylic and carbinamine stereocenters
Applications of bis and tris(aryloxy)amine ligands to main group and transition metal chemistry
Strained silanes as Lewis acids for the construction of carbon-carbon bonds
New chemical tools for interrogating biological systems: Fluorescent and luminescent lanthanide reporters
Self-assembled electrical materials from contorted aromatics
I. Bioorganic studies of rhodopsin and retinoid. II. The use of Zn-porphyrin tweezer approach for structural studies
Synthesis and applications of several curved polycyclic aromatic hydrocarbons
Development of new DNA sequencing approaches and investigation of vision-related proteins using synthetic chemistry
Strained unsaturated cyclophanes as building blocks for new materials
Harnessing substrate-enzyme plasticity: Development of fluorogenic reporters for imaging metabolism by the beta-oxidation enzymes
Investigating the origin of homochirality
Co-opting the cell machinery for directed evolution
Synthesis of natural product scaffolds with antitumor properties: Derivatives of ecteinascidin 743 and pluraflavin A
A transannular Cope approach toward the core structure of isocyclocitrinol
Total synthesis of dolabelide D
Construction of stimuli-responsive polymers and polymer networks using controlled, living polymerizations and highly efficient organic reactions
Zirconium catalysis of the asymmetric carboalumination of olefins and the chain growth of aluminum alkyls
Development of trimethoprim-based chemical tags for live cell imaging
I. Mechanism of insertion of alkynes into a constrained geometry zirconaaziridine. II. Synthesis and reactivity of titanaaziridines
C-H bond functionalization via hydride transfer: Development of catalytic C-C bond forming reactions via intramolecular coupling of sp3 C-H bonds and activated alkenes
Synthetic pyridoxamine models as transaminase enzyme mimics
Electron and hydride transfer reactions of half-sandwich ruthenium omplexes
Part I. Diels-Alder reactions of enyne dienophiles. Part II. Total synthesis of spirotenuipesines A and B. Part III. Cortistatins as inspirations for methodology development and analog synthesis
Development of fluorescent and luminescent reporters as biological imaging probes
Hydrogen atom transfer from transition-metal hydrides: Applications to radical cyclization
Synthetic applications of silicon Lewis acids: Total synthesis of MS-153 and manzacidin C
Contorted polycyclic aromatic hydrocarbons: Synthesis, structure, and function
Single-Molecules in the Break Junctions: From Conductance Measurements to Mechanochemistry
The Modification of Carbon Materials for Incorporation into Nanoscale Devices
The Stereoselectivity of the Escherichia coli Protein Synthesis Machinery
Enantioselective Mannich-type Reactions Promoted by Strained Silane Lewis Acids: Selective Generation of Two Contiguous Stereocenters and Entry into a Novel Class of Pyrrolidines
Development of Fluorescent Reporters for the Study of Metabolic Pathways and Synaptic Transmission
Development of Fluorescent and Luminescent Probes for Monitoring Biological Events
New Developments in the Chemistry of Strained Silicon Lewis Acids: Imine Allylations and Tandem Ylide Addition/Ring-Opening Reactions
C-H Bonds as Ubiquitous Functionality: The Development of New Methods for the Activation and Functionalization of C-H Bonds
Artificial Enzymes with Thiazolium and Imidazolium Coenzyme Mimics
Part I. Enantioselective Allylation, Crotylation, and Cinnamylation of Imines. Part II. Designing a Process-Friendly Synthesis of (alpha)-Kainic Acid
Part I: Development of New Methods for Multicatalysis: Bismuth(III) Triflate-Catalyzed Hydrofunctionalizations. Part II: Development of a Novel Paradigm for Nucleophilic Substitution: Aromatic Cation Activation of Alcohols
Strategies for the Controlled Synthesis of Oligomeric Natural Products
Part 1: Lanthanum(III) Triflate-Catalyzed Cyclopropanation via Intramolecular Methylene Transfer Part 2: Reaction Design with Aromatic Ions - Nucleophilic Acyl Substitution and Organophotoredox Catalysts
Part I: Development of New Methods for Application in Multicatalytic Reactions Part II: Investigation of Stable Carbenium Catalysts as Hydride Transfer Agents
Computers for Chemistry and Chemistry for Computers: From computational prediction of reaction selectivities to novel molecular wires for electrical devices
Strategic Applications of Tandem Reactions in Complex Natural Product Synthesis: Rapid Access to the (Iso)Cyclocitrinol Core
A Concise, Stereocontrolled Total Synthesis of Rippertenol
Methodological Innovations in Polyketide Synthesis and their Application toward the Scalable Synthesis of Anti-Tumor Agent Spongistatin 1