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You are viewing titles for BOSTON UNIVERSITY in the Molecular biology subject available through the ProQuest Dissertations & Theses Gradworks site.


A breadboard for synthetic gene networks A method for detection of endogenous unmodified RNA in live bacterial cells A microfluidic platform for quantitative analysis of single mycobacteria cells A role for endothelial cells in regenerative and personalized medicine A role for serum amyloid A and toll-like receptor 2 in the regulation of vascular smooth muscle cell gene expression A synthetic gene network architecture that propagates A zebrafish (Danio rerio) embryo bioassay for endocrine disrupting chemicals: Biomarkers of estrogen- and arylhydrocarbon-receptor actions and interactions AMP-activated protein kinase, Sirtuin 1, and p53 interactions in HEPG2 cells An integrated analysis of the coordinated dysregulation of microRNAs and their targets in pre-invasive breast cancer Analysis of brown adipocyte-derived VEGF-A Analysis of engulfment and cell corpse processing by epithelial cells in the Drosophila ovary Antioxidant effects on lipid turnover in human differentiated adipocytes Bacteriophage technologies and their application to synthetic gene networks Cellular, molecular, and evolutionary mechanisms of Wolbachia stem cell niche tropism in Drosophila Characterization of BK viral responses to the dual-PI3K/mTOR inhibitor dactolisib (NVP BEZ-235) in a renal cell culture model Characterization of CAL 27 and HSC-3 cell lines. DPAGT1 gene expression and association with oral squamous cell carcinoma genesis and metastasis Characterization of the S2 isolate of vesicular stomatitis virus Characterization of the brain as a site of fructose metabolism and of an aldolase B knockout mouse that mimics human hereditary fructose intolerance Characterization of the nitric oxide and adrenomedullin signaling pathways in normal and diabetic mouse retina Characterization of the role that bacterial surface polysaccharide poly n-acetyl glucosamine plays in non-vaccine serotypes of Streptococcus pneumonia colonization and pathogenicity Characterization of the structure and function of NF-kappa B essential modulator and its interaction with inhibitor of kappa B kinase beta and development of a screening protocol to discover and validate inhibitors of the interaction Characterizing rates of allelic dropout and the impact on estimating the number of contributors Characterizing the effect of transthyretin amyloid on the heart Cloning of CDNAs for estrogen receptor alpha, aromatase, and aryl hydrocarbon receptors and environmental effects on gene expression in the painted turtle (Chrysemys picta) and the red-eared slider (Pseudemys scripta) Computational analysis of chromatin features associated with transcription and recombination in yeast Consequences of mitofusin ablation in cardiac myocytes. A genetic study in mice Control of myofibroblast gene expression by transcriptional co-regulators Controlling microbial community dynamics through engineered metabolic dependencies Cytochromes P450 2B1 and 2B6: Structure-function analysis using DNA shuffling mutagenesis DNA damage response in in vitro matured oocytes Defining mechanisms directing YAP/TAZ-mediated tumorigenesis Demography, selection and comparative molecular evolution in brood parasitic indigobirds (Vidua spp.) and their firefinch (Lagonosticta spp.) hosts Determining cellular and biochemical function of a novel adhesion molecule in the kidney Determining the change in PCT efficiency with cycle number and characterizing the effect of serial dilutions on the DNA signal Developing MenaCalc: An assay to predict risk of breast cancer tumor metastasis through quantification of Mena protein isoforms Development of TDP-43 granule inhibitors as potential amyotrophic lateral sclerosis and frontotemporal lobar degeneration therapies Differential effects of epidermal growth factor receptor inhibitors on glioblastoma multiforme Double bromodomain proteins as regulators of lymphopoiesis and inflammation Effect of P21 on HIV transcription Effects of regulatory light chain phosphorylation on mutant and wild-type cardiac muscle myosin mechanochemistry Environmental PPAR-gamma agonists accelerate aging of bone and impair lymphopoiesis Evaluating the role of the Hippo pathway in the onset and disease progression of the SOD1 mouse model of Amyotrophic Lateral Sclerosis Evaluation of error and reproducibility of qPCR for absolute quantification of DNA Examining the potential of anti-A(beta) antibodies as Alzheimer's therapeutics Exploring the sources of peak height reduction during low-template, compromised DNA data analysis Expression of cohesin proteins and nano-architectural changes in rectal mucosa to assess risk of colon cancer based on field carcinogenesis Fidelity of heterozygote balance and contributor proportions before and after post-PCR purification of low template two-person mixtures Focal adhesion protein dynamics and the role of endosomes in contractile, fully differentiated, vascular smooth muscle Formalization of molecular interaction maps in systems biology; application to simulations of the relationship between DNA damage response and circadian rhythms From bacteria to humans: The CRISPR/Cas9 editing system, a novel therapeutic GPS2 nuclear localization and TBL1-mediated stabilization are important in regulating nuclear encoded mitochondrial gene expression Generating CRISPR-Cas9 genome-engineered human embryonic stem cells to model a genetic mechanism of asthma Generation of high throughput transduction tools and evaluation of the role of BMP2/4 in late morphogenesis in sea urchin embryos Genome-wide characterization of microRNA and gene expression patterns in smoking-related lung disease Genome-wide identification of BCL-3 and P50 target genes in disuse muscle atrophy Global investigation of transcriptional programs involved in cell proliferation and differentiation Heat shock transcription factor 1 and heat shock protein 72 play a critical role in HER2-induced cellular transformation and tumorigenesis Hereditary fructose intolerance: Metabolic implications and analysis of aldoB mutations Hexokinase and mitofusin 2: Mitochondrial modulators of apoptosis in ischemic acute kidney injury Human immunodeficiency virus type 1 envelope glycoprotein-dependent and -independent mechanisms of dendritic cell-mediated virus capture and trans infection IGPR-1 promotes colorectal cancer tumor cell survival and modifies the response of cancer cells to chemotherapeutics Identification of novel regulators of mesenchymal stem cell commitment to the brown adipocyte lineage Immunity against fungal beta 1,3 glucan carbohydrate in the gastrointestinal tract Immunolocalization of gene products responsible for amelogensis imperfecta and dentinogenesis imperfecta in mice Improved modular multipart DNA assembly, development of a DNA part toolkit for E. coli, and applications in traditional biology and bioelectronic systems Improving antibiotic activity by manipulating bacterial reactive oxygen species metabolism Individual and population based VEGF-endothelial cell processing is modulated by extracellular matrix stiffness Induction of antibiotic tolerance in bacteria by self-produced and inter-species signaling Innervation defects as a mechanism of childhood asthma Instrument design and optimization of interferometric reflectance imaging sensors for in vitro diagnostics Interrogating signaling pathways using transcriptomic and proteomic data Investigating combinatorial ligand addiction provides insights into rational drug combinations in cancer therapy Investigation of uncharacterized spondylocostal dysostosis using whole exome sequencing Isolating post-amplification genomic DNA for recursive analysis of low-template DNA samples MEF2A coordinately regulates a costamere gene program in cardiac muscle Manipulation of mitofusin2/ras interaction as a therapy for acute ischemic kidney injury Mapping the YY1 and p65 binding sites on the transcription factor LSF Mechanism of deoxyguanosine-rich oligonucleotide-induced cell cycle arrest in pancreatic cancer cells Mechanism(s) by which vitamin D and its metabolites inhibit prostate cancer growth Metronomic cyclophosphamide-activated anti-tumor immune responses: Dose and schedule dependence in mouse models Microfluidic platform for PCR based nucleic acid diagnostic Mitochondria and autophagy in the context of Parkinson's disease Mitochondrial dna regulates TNF-alpha mRNA stability Mitochondrial dysfunction and oxidative stress in metabolic heart disease Molecular determinants of sensitivity to poly(ADP-ribose) polymerase inhibitors in epithelial ovarian cancer Molecular mechanisms of diaphragm development: Implications for congenital diaphragmatic hernia Molecular regulation of VEGFR-2 expression and activation in endothelial cells Molecular regulation of VEGFR-2 function and expression through post-translational modifications N-glycosylation signaling pathways in oral squamous cell carcinoma N-linked glycosylation at position ASN98 of the ALK1 receptor protein: Relevance for ALK1 function and HHT pathogenesis NF-kappaB-dependent regulation of the diagnostic marker CD10 and role of BCL-2 activity in histone deacetylase inhibitor-induced apoptosis in human B-lymphoma cell lines Neuregulin/ErbB signaling and endothelial progenitor cell biology Neutrophil elastase cleaves vascular endothelial growth factor to generate a fragment with altered activity New insights into the molecular regulation of kidney disease: Contributions of APOL1 and MYH9 Optimizing conditions to electroporate Rothia mucilaginosa PI 3-kinase signaling regulates transcription through a network of NFkappaB, MYC superfamily and forkhead transcription factors Periostin signaling regulates breast cancer stem cells Phosphorylation dependent regulation of CaMKII gamma activity and its implication in vascular smooth muscle function Phylogenomic analysis of Escherichia coli methyltransferases and characterization of a novel subfamily of enzymes performing methyl transfer Porphyromonas gingivalis interactions with host innate immune mediators Production of functionally enhanced monoclonal antibodies via gene therapy Protein sorting and trafficking by neuronal adaptor proteins: Characterization of a conserved dendritic targeting motif on Kv4 channels and endocytic sorting of amyloid precursor protein by Mint2/X11L Purification of enzymatically active recombinant lysyl oxidase-like 2 protein from mammalian cells Regulated protein aggregation: How it takes TIA-1 to tangle Relevance of HIV infection to osteoblast-T cell crosstalk Replication stress and the alternative lengthening of telomeres pathway Rgc1/Rgc2 deletions cause increased sensitivity to oxidative stress in saccaromyces cerevisiae, which can be overcome by constitutive nuclear Yap1 expression Role of murine double minute 2 and retinoblastoma protein in cellular senescence and muscle cell differentiation Role of oxidative stress, inflammation and fibrosis in promoting vasculopathy in systemic sclerosis related pulmonary arterial hypertension Role of transcription factor CUX2 in post-natal development gene expression and sex-biased gene expression in mouse liver Single-molecule studies of the eukayotic translation initiation factor 4A: Helicase activity, conformational dynamics and function regulation Small molecule stabilization of A149P-aldolase, the most prevalent form of aldolase B associated with hereditary fructose intolerance Study of macromolecular interactions using computational solvent mapping Synthetic biology applications of engineered riboregulation Systems biology approaches to understanding hematopoiesis Targeted use of camptothecin as a specific pharmacological agent for the treatment of triple negative breast cancer The Alzheimer's disease-associated beta-amyloid protein is an antimicrobial peptide with a redox mechanism of action The Nrf2 transcriptional target, OSGIN1, contributes to the cytoprotective properties of dimethyl fumarate The chemokine receptor 4 (CXCR4) in primary cutaneous melanoma---correlation with established histopathologic prognosticators, BRAF status and expression of its ligand CXCL12 The difference two strands make: ETEC pili structures create paradigm shift in pilus biogenesis and an opportunity for novel antimicrobial therapeutics The effect of vitamin D2, vitamin D3 or vitamin D2 in mushroom powder supplements on broad gene expression in human white blood cells The effects of shockwaves on cultured mammalian neurons and their implications for mild traumatic brain injury The pathophysiology of plasma glutathione peroxidase deficiency The program of gene expression regulated by phosphatidylinositol 3-kinase signaling The regulation of neuroregeneration in zebrafish (Danio rerio): Global gene expression patterns and the role of estrogen and arylhydrocarbon receptor (AhR) signaling The role of ADP-ribosylation factor guanine nucleotide exchange factor-2 in endothelial response to tumor necrosis factor-alpha The role of Ikaros in Foxo1-driven gene expression in CD4 T cells The role of P130CAS complex formation in BCAR3-mediated signaling The role of bone morphogenetic protein 2 in SMA-directed angiogenesis during distraction osteogenesis The role of cavin-1 and caveolin-1 in breast cancer The role of glutamate transporters and the scaffolding protein IQGAP1 in the regulation of AMPA receptor trafficking and turnover The role of pulmonary mast cells in neurotrophin 4 mediated cholinergic neuroplasticity in neonatal asthma The role of the Golgi apparatus in neuronal polarity The role of the P2x7 receptor in injury-induced calcium dynamics and cell migration in the corneal epithelium The role of the aryl hydrocarbon receptor in megakaryocyte development The role of the aryl hydrocarbon receptor in the development of cells with molecular and functional characteristics of breast cancer stem cells The role of the constitutively active aryl hydrocarbon receptor in mammary tumor progression The role of vascular endothelial growth factor in heart failure with preserved ejection fraction Transcription initiation by the respiratory syncytial virus polymerase Translational assessment of primary tumor-derived cells Two functions of lysyl oxidase like-2: Extracellular matrix maturation and cell proliferation Y-family DNA polymerase architecture: Three structural features control accurate deoxy CTP insertion opposite N2-deoxy-guanine-benzo-a-pyrene