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You are viewing titles for BOSTON UNIVERSITY in the Bioinformatics subject available through the ProQuest Dissertations & Theses Gradworks site.


A design-build-test-learn tool for synthetic biology A module based approach for identifying driver genes and expanding pathways from integrated biological networks Affecting the macrophage response to infection by integrating signaling and gene-regulatory networks Algorithms for reconstruction and analysis of metabolic networks, with an application to Neurospora crassa An integrated analysis of fibroblast morphology and migration on bioengineered substrata aided by machine vision and learning techniques Analysis of molecular interactions in the presence of side chain flexibility Applications and characterization of mRNA expression compendia in inference of genetic association networks Bioinformatics tools for the elucidation of genomic properties Biological network models for inferring mechanism of action, characterizing cellular phenotypes, and predicting drug response Characterizing the Huntington's disease, Parkinson's disease, and pan-neurodegenerative gene expression signature with RNA sequencing Clustering and network analysis with biological applications Comparative metagenomics to identify functional signatures in the human microbiome Computational analysis of chromatin features associated with transcription and recombination in yeast Computational approaches for whole-transcriptome cancer analysis based on RNA sequencing data Computational approaches to deciphering regulatory circuits in Mycobacterium tuberculosis from chip-seq data, and developing theoretical strategies to combat drug-resistant infections. Computational approaches to understanding infectious disease De novo sequencing of heparan sulfate saccharides using high-resolution tandem mass spectrometry Decoding function through comparative genomics: From animal evolution to human disease Determinants of protein evolution: From residues to networks Developing genomic models for cancer prevention and treatment stratification Distributed analyses of disease risk and association across networks of de-identified medical systems Effects of template mass, complexity, and analysis method on the ability to correctly determine the number of contributors to DNA mixtures Enabling clinical genomics by reducing false discovery in next-generation sequencing data Formalization of molecular interaction maps in systems biology; application to simulations of the relationship between DNA damage response and circadian rhythms Gene network analysis of type 2 diabetes mellitus Genome-wide characterization of microRNA and gene expression patterns in smoking-related lung disease Genome-wide expression and genomic data integration analyses in sporadic Parkinsons disease Genome-wide identification of BCL-3 and P50 target genes in disuse muscle atrophy High throughput genotyping and fingerprinting of Mycobacterium tuberculosis multi-drug resistant strains Identification of gene-gene interactions for Alzheimer's Disease using co-operative game theory In silico bacterial gene regulatory network reconstruction from sequence Inference of a genome -wide regulatory network for the metal -reducing microbe Shewanella oneidensis MR-1 via a compendium of microarrays Interrogating signaling pathways using transcriptomic and proteomic data Isolating post-amplification genomic DNA for recursive analysis of low-template DNA samples Large-scale single-cell transcriptomics of osteosarcoma reveals extensive and different heterogeneity in primary tumors versus murine xenograft model Machine learning methods in construction of transcriptional regulatory networks Metabolic networks and cross-feeding in microbial communities Metabolism in the human microbiome, from the single organism to the community level Modeling human muscle metabolism: Using constraint-based modeling to investigate nutrition supplements, insulin resistance, and Type 2 Diabetes Network analyses of proteome evolution and diversity New methods for studying complex diseases via genetic association studies Optimization methods for side-chain positioning and macromolecular docking Phylogenomic analysis of Escherichia coli methyltransferases and characterization of a novel subfamily of enzymes performing methyl transfer Postmortem iris recognition and its application in human identification Precision medicine in oncology: A complicated idea needs a simple solution Reannotation and consolidation of microarray probes for the meta-analysis of gene expression across multiple cell types Reconstruction of lipid metabolism regulatory network in Mycobacterium tuberculosis Role of growth hormone and chromatin structure in regulation of sex differences in mouse liver gene expression Roles of miR-155 in microglia and neurogenesis in response to toll-like receptor mediated inflammation Sequence-and structure-based approaches to deciphering enzyme evolution in the haloalkonoate dehalogenase superfamily Statistical methods for analyzing sequencing data with applications in modern biomedical analysis and personalized medicine Structured clustering representations and methods Study of macromolecular interactions using computational solvent mapping Study of protein-macrocycle interactions for lessons in drug design Surfing the dynamics in genomes: Regulation of moved genes in Drosophila and the expansion of an apoptosis regulatory gene family in eukaryotes Systems biology approaches to understanding hematopoiesis The interdependence between environment and metabolism in microbe sand their ecosystems The prediction of hla genotypes from next generation sequencing and genome scan data Transcriptomic analysis of dietary hypophosphatemia shows downregulated oxidative metabolism in fracture callus tissues Using the host immune response to hemorrhagic fever viruses to understand pathogenesis and improve diagnostics