God locus of health control and worry have been associated with health-seeking attitudes and behavior. This aim of this study was to examine perceptions of God control themes, emotions, and cancer screening attitudes and behavior among African American men from different socioeconomic backgrounds. The sample included African American men (N = 364) between the ages of 50 and 70 with no prostate cancer diagnosis. Of significant interest in this study was examining the way different levels of worry and levels of socioeconomic status (SES) would change the relationship between God locus of health control (GLHC), health-seeking factors, and screening attitudes. Men from a lower socioeconomic status reported lower screening intent and less testing compared to men from the higher SES group. Men in the low SES group reported higher levels of worry and less screening intent. SES, GLHC, and worry are important factors that may influence prostate-cancer screening in African American men.