Sexual assault of women in childhood and adulthood is pervasive and associated with a range of physical and mental health sequelae in adulthood, including increased sexual focus, as evidenced by larger numbers of partners and earlier sexual debut; and sexual avoidance, as indicated by higher rates of sexual dysfunction relative to non-assaulted women. In Study 1, we compared women's sexual behavior and attitudes following no sexual assault or sexual assault in childhood only, adulthood only, or childhood and adulthood in a large sample of sex research volunteers (n = 358). Women assaulted in childhood and adulthood reported higher rates of sexually focused behavior including higher numbers of sexual partners and earlier sexual debut, but did not report higher rates of sexual avoidance compared to non-assaulted women. Study 2 was a laboratory study (n = 64) in which we compared women's likelihood of engaging in risky sex with a novel partner based on alcohol condition (receive alcohol vs. receive no alcohol) and assault history (child sexual assault only, adult sexual assault only, or no assault). Study 2 findings revealed that women assaulted in childhood reported less likelihood of condom use and sexual intercourse compared to other women. Women who received alcohol reported greater likelihood of engaging in risky sex than did women who did not receive alcohol. Assault history and alcohol condition interacted such that intoxicated women assaulted in childhood reported greater likelihood of unprotected oral sex relative to other groups. Implications for theory and prevention programs are discussed.