Information technology has the potential to support cooperation and facilitate organizational learning. However, technology use, cooperation, and organizational learning are complex constructs that were often oversimplified and resulted in inconsistent findings in past studies. This study employed an innovative approach to building new knowledge about the use of technology in support of cooperative work and organizational learning in a health care setting. This study examined the use of the Patient Safety Network (PSN) within the University of Missouri Health Care (UMHC). The purpose of this study is to understand in what ways and to what extent health care practitioners at UMHC used the PSN and how it influenced cooperative work and contributed to organizational learning. Activity was used as the unit of analysis to examine members’ actions and interactions surrounding a common patient safety activity that were recorded by the PSN. Follow-up surveys of perceived organizational learning were collected at the end of each patient safety activity. The findings of this study provide evidence that technology use and cooperation can be operationalized and examined in context and demonstrate how it can be done reliably. Three types of PSN technology use were found: Event Complexity, Appropriation of Reporting, and Appropriation of Resolution. The results show the importance of understanding the participation of different roles within a CSCW context and of considering task characteristics, such as event complexity. The degree of cooperation depended on how well the basic elements were met. The results indicate that at the time of the study, those using PSN show evidence of working cooperatively through the system, but in general are not scoring high on the indicators of cooperation. Additionally, the overall relationship between cooperation and organizational learning was found weak. Finally, the results show that factors of technology use impact levels of cooperation and perceived organizational learning. The overall cooperation was influenced by the levels of Appropriation of Reporting as well as by the interaction between the level of Event Complexity and Appropriation of Reporting. More specifically, the higher the Appropriation of Reporting, the higher the overall cooperation was found. Event Complexity reduced the effect of Appropriation of Reporting on the overall cooperation. The overall perceived organizational learning was influenced by the levels of Event Complexity and Appropriation of Resolution. More specifically, the higher the Event Complexity, the lower the overall perception of organizational learning. Extremely high and extremely low overall scores on Appropriation of Resolution had higher perceptions of organizational learning.