This research study examined the sexual satisfaction of heterosexual married women who have polycystic ovary syndrome (PCOS). A sample of 150 women was self-selected via links on websites dedicated to PCOS support and information as well as flyers posted in public areas of a local health clinic. Each participant completed 5 instruments: Global Measure of Sexual Satisfaction (GMSEX; “Interpersonal Exchange Model of Sexual Satisfaction Questionnaire,” Lawrance & Byers, 1998), Kansas Marital Satisfaction Scale (KMS; “Characteristics of the Kansas Marital Satisfaction Scale in a Sample of 79 Married Couples,” Schumm, Scanlon, Crow, Green, & Buckler, 1983), Center for Epidemiological Studies–Depression (CES–D; “The CES-D Scale: A Self-Report Depression Scale for Research in the General Population,” Radloff, 1977), Body Image Quality of Life Inventory (BIQLI; Body Image Quality of Life Inventory, Cash & Fleming, 2002), and the Penn State Worry Questionnaire (PSWQ; “Development and Validation of the Penn State Worry Questionnaire,” Meyer, Miller, R. L. Metzger, & Borkovec, 1990). In the final regression analysis, PCOS was not found to be a significant predictor of sexual satisfaction. The 7 factors considered accounted for 80% of the variation in sexual satisfaction, supporting recommendations for future research on married women with PCOS.