In the 21st century, Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS), commonly known as HIV/AIDS, are still major killers in the African American community. This Mediated regression study investigated how personality traits may affect HIV awareness in African American men between the ages of 25 and 44. I investigated the literature review some of the historical barriers, such as lack of access to services; beliefs, perceptions, and myths; and the relationship between sociocultural issues that affect the prevalence of this disease in the African American community. I conducted a cross-sectional non-experimental quantitative research study with hypothesis testing to determine how adult personality constructs may influence HIV awareness. Information was collected using a cross-sectional research approach where attitudes about HIV awareness and self-evaluation of personality constructs were collected at a single point in time. The sample population consisted of 200 African American adults between the ages of 25 and 44, inclusive.