This study examines the utility of a clinically-derived short form of the Wechsler Adult Intelligence Scale, Third Edition (WAIS-III) for an adult male population infected with HIV. The primary hypothesis for this study is that a clinically-derived short form can be an acceptable substitute for the full administration of the WAIS-III in a population of individuals infected with HIV. Ninety records were selected from a private practice in Chicago meeting the criteria that subjects self-identified as HIV-positive and completed a full WAIS-III battery. These records were then rescored with an algorithm used to define a clinically-derived abbreviation (CDA) of the WAIS-III (Wymer, Rayls, & Wagner, 2003). The estimates derived from the CDA were compared to the values from the full administration of the WAIS-III. A short summary of the current state of HIV is presented, along with a review of the literature on intelligence testing and short forms of intelligence tests. The study shows that the CDA correlates highly (r > .90) with the full administration, but additional utility criteria developed by Resnick and Entin (1971), such as insignificant mean IQ differences between the CDA and full administrations of the WAIS-III and greater than 90% descriptive category placement accuracy, are not met for the IQ scores and most of the individual subtests. Suggestions for extensions of the study are also provided.