Pregnancy is a time of transition and identity formation for women and is commonly conceptualized as a time of excitement and joy. Mood disorders are an unwelcome part of pregnancy that can have serious negative impacts on mothers, children and partners. Recently developed group prenatal care programs such as Centering Pregnancy (CP) present unique opportunities for screening and supporting women, but are not currently well-researched. The purpose of this pilot study was to begin to explore the mood and prenatal care experiences of women in CP group prenatal care utilizing both quantitative and qualitative methods. Twenty-four African American CP participants were screened for depression (EPDS) and anxiety (STPI-A) early in CP and at the end of their care. Ten patients were interviewed about their mood and prenatal care experiences. Of those screened, 10.5% of women screened with possible depression at Time 1 and 5.6% at Time 2. No participants screened with high anxiety. Depression scores trended downward by the end of CP care at a level nearing statistical significance (p = .058). Anxiety scores did not change. Both non-significant findings may be attributable to small sample size and low screened levels of mood. Women's interviews suggest that CP is a promising context for getting information and support from others, learning about pregnancy, telling one's story and feeling a part of a something. While preliminary and mixed, these findings suggest that further research into CP as a context for mood disorder screening and social support may be warranted.