Acculturation and adjustment is a topic that has been and that continues to be studied with immigrant populations. This study was an attempt to examine if acculturation is associated with adjustment in Nigerian women. The study hypothesized that high acculturation levels would lead to low depression scores and high self-esteem levels. Additionally, this study also hypothesized that low acculturation levels would predict high levels of stress and anxiety. Finally, this study examined levels of acculturation and marriage. A sample included 82 Nigerian women who volunteered to participate from a religious organization. The Measures utilized were Acculturation Stress Scale (ACS), Rosenberg Self- Esteem Scale (RSE), Depression, Anxiety, and Stress Scale (DASS); and the Collective Self-Esteem Scale (CSE). All of these variables namely depression, anxiety, stress, self-esteem, and some demographic information were studied with acculturation. The results showed that women with higher acculturation levels reported significantly less symptoms of depression, anxiety, and stress than women with lower acculturation in this group reported. In regard to self-esteem (collective & personal) and acculturation, the results indicated that higher acculturation levels correlated with reported higher self-esteem. Additionally, the results indicated that women who were married were trending higher acculturation levels compared to single women in the study. The results validated the original hypotheses. It is also interesting to note that the results are consistent with several studies on acculturation.