Human papillomavirus (HPV) is a common sexually transmitted infection in the United States. The virus is linked to cervical cancer. Research has revealed a lack of knowledge among African American women about HPV. This lack of knowledge can influence how women perceive the information and understand preventions related to this sexually transmitted disease. The purpose of this quantitative study was to determine whether this lack of knowledge is related to education, age, socioeconomic status, and marital status using chi-square and t-tests for univariate analysis and multiple regression to control for confounding. The social cognitive theory was used to explain the relationship between the independent variables and lack of knowledge about HPV. A sample of 334 African American women members of a graduate sorority from 4 metropolitan chapters in the southeastern United States was surveyed. Univariate analysis showed participants who were not married scored higher in HPV knowledge than those who were married. The regression analysis was statistically significant and indicated that only 15.4% of the variation in HPV knowledge is explained by the independent variables. This study, although limited in terms of generalizability to all African American women, was one of the first to explore factors related to lack of HPV knowledge in the age group beyond college. The results can contribute to positive social change by adding to our understanding of the factors related to knowledge about HPV and translating this into education programs that target specific subgroups of African American women. Future research should focus on extending the study to a broader sample.