Roles and functions of health information professionals are evolving due to the mandated electronic health record adoption process for healthcare facilities. A knowledgeable workforce with computer information technology skill sets is required for the successful collection of quality patient-care data, improvement of productivity, and decision-making processes in the healthcare environment. With a lack of research on the preparation needs of health information technology (HIT) professionals, the correlation between computer training in an HIT program and outcome expectations when using a computer for future job tasks mediated by computer self-efficacy (CSE) was investigated in this quantitative study. The online survey was completed by 245 students from 28 HIT programs throughout the United States. The assessment included self-reported demographics, CSE level, computer experience, and outcome expectations, both personal and based on performance. CSE, a concept derived from the roots of self-efficacy, was used as the framework to understand the relationship of the mediator to the variables. Multiple regression analysis indicated that the influence of computer experience on outcome expectations was at least partially mediated by CSE. These results provide useful information to health information educators in understanding the importance of computer experience when designing appropriate training curricula. The potential for social change is the investment of future health IT professionals in a dynamic knowledge base that will facilitate the transition, implementation, and continuing management of today’s health information systems, systems that support critical goals in the healthcare field for data integrity and security, as a result of the move to electronic information exchange.