Past research has suggested that optimism and pessimism are related to physical adjustment. This study examined dispositional optimism and its relationship with physical adjustment and whether this relationship may be moderated by locus of control or health locus of control. It was hypothesized that there would be a statistically significant linear relationship between dispositional optimism and physical adjustment. It was also hypothesized that locus of control and/or health locus of control moderates the relationship between dispositional optimism and physical adjustment. Data were collected solely through point-intime, self-report measures by a group of 71 participants (62 for purposes of hypothesis testing due to removal of missing or invalid responses). This study used self-report measures including a background questionnaire and measures specifically examining dispositional optimism, general locus of control, health locus of control, physical adjustment, and physical symptoms. From statistical analysis, the present study found that greater dispositional optimism was associated with greater health status, greater vitality, and less vulnerability to illness. The findings of the current study are consistent with these previous findings by demonstrating that optimists have greater physical adjustment and report themselves to be in better overall health. Despite expectations, there was no indication of an interaction between optimism and general locus of control or health locus of control in terms of physical adjustment. Limitations of the study, including possible confounding variables, and future directions for research were discussed.