In the past 3 decades, citizens of Ghana sought learning from western nations and returned to Ghana to contribute their skills and talents to nation building. However, a recent World Bank study affirmed that 47% of Ghana's college educated citizens now live abroad. The research literature on why college educated Ghanaians do not return to Ghana is limited. The central research question explored the factors that contributed to the decision of Ghanaian college graduates to remain in the United States or to return to Ghana. The conceptual framework was based on the work of Iredale, Naicker, and Getahun who argued that the migration of highly skilled and educated professionals negatively impacts a country’s social and economic development. This qualitative study used a multiple case study design. Data were collected from 6 participants, using multiple sources of evidence that included individual interviews, observations of home environments, and artifacts such as passports and diplomas. Coded and categorized data were examined for themes, patterns, and relationships. College educated professionals leave Ghana primarily to earn advanced degrees and to achieve a higher standard of living. Political corruption, poor health services, and weakened communication and transportation systems prevent them from returning to Ghana even though political instability is no longer a problem. Recommendations include the improvement of telecommunications, roads, railways, and power plants; establishment of international universities; a crusade against corruption, and development of a better health care system. Implications for social change include retaining college educated Ghanaians and using this human capital to improve the political, economic, and social conditions of Ghana.