This study identified best practices for confidential workplace depression screenings for employees. Valuable information was received from directors who are already performing well in encouraging employees to seek early treatment for depression. Best practices were identified to show how the workplace can play a lead role in increasing awareness of the costs of untreated and undetected major depressive disorder. Interviews resulted in the identification of nine best practice themes: Accessibility, Employee Assistance Programs, Online, Company Webpage, Education, Gender Differences, Anonymous, and Measuring Effectiveness. This research supports the importance of safety and health in the workplace. Depressive disorders can result in a diminished quality of life, economic losses, and increased use of health services. Depression can be mild and self-limited, or severe enough to lead to suicide. Depression, be it detected or undetected, can contribute to lower productivity, more absenteeism from the workplace, increased use of medical and mental health benefits, substance abuse, poor job satisfaction, and workplace accidents. This research supports the importance of safety and health in the workplace by showing how best practices can be an alternative resource to provide screenings for depression.