I examine how mnemonic codification in Ohio Hopewell iconographic imagery was intertwined with enacting ritual renewal through memory-work. I illustrate how the cyclical production, use, and disposal of this iconographic imagery were important aspects of the way that Ohio Hopewell communities organized their mnemonic and sacrificial regimes. I focus on a series of analytical issues. First, I theorize the relationship between material symbols, mnemonic codification, and conventionalization. I argue that the logic of sacrificial economies is based on the reiterative (repetitive) production of material symbols using often ancestral immaterial knowledge or templates. Second, I theorize and contextualize the Ohio Hopewell sacrificial economy based on the archaeological sequence in Ohio, and various ethnohistoric and ethnographic examples. I contend that comparing the Ohio Hopewell sacrificial economy to a combination of ethnographic and ethnohistoric cases yields robust results because it allows “an interpretive model to be built up by appeals to a number of sources, each of which brings into view different, otherwise unknown, features of the subject” (Wylie 1982:106). Third, I analyze Ohio Hopewell symbols from Tremper, Hopewell, and Mound City to detect and identify specific relational and contextual uniformities in how they used various elements/motifs. I document through pre-iconographic descriptions and iconographic analyzes how various elements, numeric patterns, and spatial patterns were used in the symbols from these sites. I also employ an iconographic analysis that traces the use of particular motifs and constellations of motifs in order to “decipher” the meaning of some of the more codified representations. Along these lines, I argue for some contextually specific interpretations of the meanings invested in and communicated by particular Ohio Hopewell symbols.