The study was a critical, naturalistic, and emergent case study that examined the coping strategies developed and employed by 6 mothers raising 2 children each with an autism spectrum disorder (ASD). The research was conducted using Robert Yin’s (1994) case study model. The study investigated maternal psychosocial, spiritual, and emotional coping mechanisms that mothers apply in their daily lives to balance stressors brought by raising children with ASDs. This model incorporates a formal hypothesis based upon and integrating one or more theoretical constructs. The theoretical constructs that were used in this research are based upon Albert Bandura’s (1986) social learning theory of self-efficacy and transactional model of stress and coping. As there has been little qualitative research done in this area of ASDs, this study was conducted to fill in the gaps of both qualitative and generalized research literature. Nonconventional qualitative methodology used included interviews with narratives and journaling exercises that span a period of 4 weeks. The goal of the research was to supply emergent data on mothers’ coping agendas with material self-efficacy perception to be incorporated into therapeutic and psychoeducational models for intervention and instruction to aid mothers in families in which ASDs are prevalent.