Research demonstrates that high levels of work-related burnout exist among clergy members across denominations and locations. The conservation of resources (COR) model has come to be the primary theory for explaining burnout, yet its applicability has not been tested among clergy members. The present study applies results from the Conservation of Resources Evaluation to investigate how resource loss, threat of loss, and resource gain impact coping resources and levels of work-related burnout among Nazarene pastors specifically. Five scales of the Coping Resources Inventory (CRI) (cognitive, social, emotional, spiritual/philosophical, and physical) were assessed in three stepwise regression analyses using indicators of burnout as dependent variables (exhaustion, cynicism, and professional efficacy). Results suggest that cognitive coping accounted for 37.9% of the variance in professional efficacy, emotional coping accounted for 25.3% of the variance in exhaustion, and cognitive coping for 33.4% of the variance in cynicism. Results also demonstrate that actual loss impacted scores in every domain of the CRI, which adds value for the utility of the conservation of resources model on work-related burnout. Threat of loss impacted social, emotional, and cognitive resources. Actual loss also influenced all domains of work-related burnout on the MBI. Threat of loss shared a relationship with exhaustion and cynicism only. Resource gains were not significantly related to any of the CRI or MBI scores. Findings from this study contribute to social change among pastors by narrowing the focus of particular coping resources associated with burnout. Ameliorating work-related burnout will promote some aspects of psychological wellness among pastors that could allow pastors to better serve the spiritual needs of congregants.