Regulation of positive regulatory domain I- binding factor 1 and its role in Mantle cell lymphoma
by Desai, Shruti, Ph.D., UNIVERSITY OF SOUTH FLORIDA, 2010, 178 pages; 3425661

Abstract:

The human positive regulatory domain I binding factor 1 (PRDI-BF1/PRDM1) promotes differentiation of mature B cells into antibody secreting plasma cells. In contrast ectopic expression of PRDM1 in lymphoma cells can lead to inhibition of proliferation or apoptosis. However, little is currently known about the regulation of PRDM1. The first study presented demonstrates that in lymphoma cells stimulation through the B cell receptor rapidly induces endogenous PRDM1 at the level of transcription. This study provides evidence that the PRDM1 promoter is preloaded and poised for activation in the B cell lines. The transcription factor PU.1 is shown to be required for B cell receptor induced expression of PRDM1 in lymphoma cells and in PU.1 positive myeloma cells. Furthermore, activation is associated with loss of the co-repressor TLE4 from the PU.1 complex.
 
AdviserKenneth L. Wright
SchoolUNIVERSITY OF SOUTH FLORIDA
SourceDAI/B 71-11, p. , Oct 2010
Source TypeDissertation
SubjectsMolecular biology; Immunology; Oncology
Publication Number3425661
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