Work-related musculoskeletal disorders (WRMSD), specifically physical and muscular discomfort in the upper arm, lower arm, thigh, lower leg, wrist, shoulders, back, or neck, are among the most frequently reported workplace injuries in the United States. The dearth of knowledge about the types of workloads that may contribute to the development of WRMSD was the impetus of this research. The study aimed to identify antecedents of WRMSD among warehouse workers in order to reduce WRMSDs and increase productivity as expressed in a systems perspective on industrial health. The research questions examined the prevalence of specific WRMSDs, the relationship of high-risk tasks of warehouse personnel with WRMSD incidence, and the relationship of job category and workload with WRMSD incidence. The sample included 82 warehouse workers, stockroom clerks, and forklift drivers. MANOVA was used as the data analysis technique. The results showed that WRMSD was the most prevalent in the upper back, lower back, knees, and lower legs. Various high-risk tasks were linked to WRMSD incidence including repeatedly bending to lift objects was associated with discomfort in the lower back, shoulders, and lower legs. Furthermore, the use of pallets led to reduced discomfort and work interference in the hips and buttocks, upper arms, and knees. Proper lifting form may reduce WRMSD in the shoulders, forearms, lower back, and wrists in particular. The social change implications of this study stem from the notion that increasing the employers’ WRMSD prevention awareness will lead to an increase in safety attentiveness and decrease workers’ injuries.