Patient education is an essential aspect of treatment for depression within underserved primary care settings. Several barriers currently inhibit the successful dissemination of patient education including lack of provider time, lack of patient interest and low patient literacy levels. This pilot study purposed to evaluate the acceptability of and potential impact of iPod use on patient education in the treatment of depression in medically underserved primary care settings. This purpose was accomplished by utilizing both qualitative and quantitative methods to assess patient and provider responses to this form of patient education. Although limited in its scope as a pilot study, initial results indicate that both patients and providers responded positively to the podcasts and the podcasts themselves represent one possible solution to current patient education barriers in primary care settings. Future studies are needed to confirm this outcome and to provide insight into other areas of clinical usefulness such as implementation of treatment recommendations and symptom reduction.