Traditional silicon-based circuitry is susceptible to security attacks as a consequence of the static nature of its design. Once a circuit is obtained by an attacker, it is a matter of time before one can reverse engineer its configuration. To circumvent such tampering, circuits must be dynamic by nature. A DNA-based design enables circuitry to be based on biochemical and environmental stimuli. As a first step, biological methodologies have been developed to mimic existing silicon-based technologies in information storage, random number generation, and a shift register. With each of these new theories introduced, we move closer to the practical applications afforded by DNA computing. It is unrealistic to predict that DNA computing will form the sole basis of the next generation of technology; however, when combined with current technologies, it could form a hybridization capable of achieving the fast computational benefits of DNA with the flexibility of current silicon. Regardless of what the future may hold, this research further develops DNA-based methodologies to mimic digital data manipulation.