In the United States, coronary artery bypass grafting (CABG) is one of the most common procedures for treating coronary artery disease, with more than 650,000 people undergoing the surgery each year. Given the prevalence of coronary artery disease and surgical treatment, it is important to identify psychological factors associated with disease process and outcome. Multidimensional health locus of control (HLC; Wallston, Wallston & DeVellis, 1978) is one construct that has been linked to mood and physical functioning among several medical populations (Wallston, 2005). Despite the frequent study of HLC dimensions, they have not been reliably examined among patients with coronary artery disease (e.g., see Barry, Kasl, Lichtman, Vaccarino & Krumholz, 2006). The purpose of the present study was to examine the relations among HLC dimensions, depression, and physical functioning across time in a sample of male veterans who underwent CABG at a large medical center. Using archival data collected from 58 CABG patients, mixed between-within subject analyses of variance (ANOVA) were conducted to separately assess the different influences of HLC level on depression and physical functioning from one-day pre-operation to one-month post-operation. Health locus of control dimensions were dichotomized to create groups defined by low and high scores for each dimension. It was predicted that main effects for IHLC group and CHLC group for depression would emerge. An interaction between PHLC group and depression severity across time was predicted. With respect to physical functioning, it was predicted that main effects for IHLC group and CHLC group would emerge. Last, an interaction between PHLC group and physical functioning across time was predicted to emerge. Inconsistent with predictions, analyses revealed some support for difference in depression between CHLC groups, with individuals having high CHLC reporting a tendency for lower depression than individuals with low CHLC. A significant interaction between level of internal HLC and time with respect to depression was found that was not predicted. No support was found for hypothesized relations among HLC dimensions, physical functioning, and time. Reasons for the inconsistency between this study's predictions and findings are explored, potentially guiding future researchers' use of HLC dimensions.