The relationship between depression and spirituality is unclear. This uncertainty has resulted in a lack of consensus for spirituality mechanisms and less than optimum clinical resources for people suffering with depression. Spirituality mechanisms consist of distinct personal beliefs, values, practices, and mysticisms regarding a relationship with a divine other. The power and biology of belief theory suggests spirituality mechanisms determine emotional wellness. The purpose of the study was to explore the association of six spirituality mechanisms with depression diagnosis and severity to answer a key research question that involved understanding whether levels of spirituality mechanisms significantly predict either a depression diagnosis or depression severity level. This cross sectional design employed self-administered surveys. A convenience sample of 60 noncrisis depressed clients at a behavioral health center participated in the study. A multiple binary logistic regression revealed that awareness, disappointment, realistic acceptance, grandiosity, instability, and impression management failed to predict major depressive disorder and other depressive disorder. A multiple regression revealed that mechanisms also failed to predict depression severity. The small sample size limited the study. The identity and level of standardized spirituality mechanisms that influence depression remain undetermined. Consequently, a need for further study exists. Advances in spirituality and depression research will promote positive social change as researchers standardize mechanisms as effective clinical resources. Incorporation of spirituality in professional practice will alleviate suffering for the 70% of people with unresolved depression symptoms and help lower the overall cost of healthcare.