This study discusses the theoretical, practical, and procedural role that spiritually-based marketing plays in modern commercial exchange. It stems from the research problem identification that, from a Christian perspective, it is the absence of Christ-centered principles in most corporate environments that contributes to the corrupted choices that are made on the part of decision-makers. The study begins by presenting recent scholarly arguments of the linkage between marketing, spirituality, and the practice of Lectio Divina (sacred reading). It examines the historical perspective of marketing practice and a discussion of the fundamental theories that are essential for modern-day marketing success. Next, an analysis of Christian spirituality in the context of the sixth century Benedictine practice of Lectio Divina is researched. Among the various notions of spirituality existing cross-culturally, both religious and secular, this research examines spirituality from a Christ-centered perspective. Scholarly evidence is presented to support the belief that there exists a fundamental connection between business marketing and Christian spirituality. The practice of Lectio Divina is presented as the vehicle for achieving spiritual guidance for marketing decision-making. The creation of a Lectio guide that emulates the procedural movements of the practice by cross-referencing Scriptural directives to specific business marketing situations is tested by way of quantitative and qualitative research. A group of students attending a Christian University are surveyed in order to determine the guide's effectiveness. The primary finding is that, through engagement in the Lectio praxis, the participant experiences a metanoia or change of heart, as reported by the test group. An additional finding was that those who claimed to not be particularly religious likewise derived a significant benefit. These findings represent a key contribution to the body of knowledge relative to effective marketing decision making technique. Although the focus of this research was with participants who were Christian believers, further study should explore the use of Lectio Divina by people who are not Christian believers in order to determine if a congruent benefit is experienced. Likewise, further study is required to determine effectiveness outside of the field of marketing and with a broader population.