Direct analysis of samples by mass spectrometry: From elements to bio-molecules using laser ablation inductively coupled plasma mass spectrometry and laser desorption/ionization mass spectrometry
by Perdian, David C., Ph.D., IOWA STATE UNIVERSITY, 2009, 145 pages; 3369879

Abstract:

Mass spectrometric methods that are able to analyze solid samples or biological materials with little or no sample preparation are invaluable to science as well as society. Fundamental research that has discovered experimental and instrumental parameters that inhibit fractionation effects that occur during the quantification of elemental species in solid samples by laser ablation inductively coupled plasma mass spectrometry is described. Research that determines the effectiveness of novel laser desorption/ionization mass spectrometric methods for the molecular analysis of biological tissues at atmospheric pressure and at high spatial resolution is also described. A spatial resolution is achieved that is able to analyze samples at the single cell level.
 
AdviserRobert S. Houk
SchoolIOWA STATE UNIVERSITY
SourceDAI/B 70-08, p. , Oct 2009
Source TypeDissertation
SubjectsAnalytical chemistry
Publication Number3369879
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