Colorectal cancer is known to be among the most common malignancies globally (Fazeli et al., 2007). Due to the high volume of Central/Middle Eastern Muslim immigration to the United States and the large population in North Texas, a need was recognized for health educators and health professionals to provide culturally competent care. Knowledge, attitude, belief, and self-efficacy as well as screening practices of this ethnic group were identified as the foundation for this study. This study measured subjective issues that have direct impact on adherence to the American Cancer Society guidelines in regard to colorectal cancer screening. Furthermore, this study served as a needs assessment for the development of culturally relevant CRC screening among Central/Middle Eastern population living in United States. The overall summary revealed that the participants who were knowledgeable about the colorectal cancer and associated procedures demonstrated more willingness to comply with screening procedures. Additionally, participants with higher self-efficacy scores evidenced more willingness to be screened for colorectal cancer and participants with higher belief scores were also more willing to be screened for colorectal cancer. The key finding in this study surrounded respondents' income level specifically, those who had higher levels of income were more willing to be screened for colorectal cancer.