Language is a complex higher order cognitive function and has been one of the most popular areas of research over the past two centuries. Impairment of the ability to produce and/or comprehend language, also called aphasia, is a common functional disability seen in many stroke patients. Cerebral function reorganization immediately post-stroke and over a period of therapy can predict extent of damage and final outcome of recovery in these patients. A thorough understanding of how the brain rewires post-stroke can help clinicians to make informative decisions about rehabilitation strategies most appropriate for an individual patient. The goal of this dissertation was to use currently existing neuroimaging techniques—functional MRI (fMRI), diffusion tensor imaging (DTI), electroencephalography (EEG) and resting state BOLD MRI—to develop a multi-modality neuroimaging tool to study brain plasticity in aphasia patients. Using fMRI as a focal point for integration of all modalities, we have developed and investigated methods to combine information from these modalities and identify potential markers of cerebral reorganization. We hypothesize that individual task difficulty maybe a critical confound in interpreting changes in brain function in stroke patients. Using our developed battery of language production and comprehension tasks, we have shown that task difficulty effects in language function can be highlighted in healthy subjects and are also found to change with age. This developed tool will be useful for future studies of aphasia stroke patients in evaluating effects of clinical drugs and different rehabilitation strategies in successful recovery of these patients.