Obtaining a college education is often difficult for single mothers due to scheduling problems and childcare needs. Online learning has become a viable option for single mothers to obtain a college degree. This study examined the experiences of single mothers to identify factors that influenced their enrollment and persistence in online learning. Fourteen single mothers enrolled at a community college in Georgia responded to a survey and an open-ended interview to provide information about themselves and their experiences with online courses. The survey provided demographic and personal information about the participants. The questionnaire provided information about participants’ decision to enroll in online courses, their motivation to persist in the courses, and information about their attitudes toward online courses. An analysis of the data obtained from the surveys and the interviews identified factors that influenced single mothers’ selection of and persistence in online courses. Childcare/babysitting was identified as the number one factor that influenced single mothers to decide to enroll in online courses, but degree completion was the motivating factor. Overall, participants reported positive attitudes toward the online delivery method and the majority preferred online courses to the traditional classroom method. The results further found that external factors including personal, institutional, course, and instructional factors impacted the participants’ online learning experiences. The data further identified challenges encountered by the participants as they completed the online courses. Additionally, the data provided information about the participants’ perceptions about course design, instructor communication, and technology that impacted their level of success in the courses. This qualitative research study added to the body of research relating to online course enrollment patterns of single mothers and strategies used by single mothers to complete the online courses. Data obtained from this study may be used to help educators better understand single mothers’ needs and concerns about online courses which in turn could help postsecondary institutions improve their online learning experiences.