Development and investigation of unique organic materials to detect disease biomarkers
by Samoei, George Kiplimo, Ph.D., PORTLAND STATE UNIVERSITY, 2008, 110 pages; 3346721

Abstract:

Chemomechanical polymer gels with the capability of recognizing specific biological molecules are promising materials for many biomedical applications. Glucose-selective hydrogels have potential utility in the continuous monitoring of glucose and glucose-triggered insulin delivery for the management of diabetes. Herein, the development and study of the first material which detects glucose via significant volume changes in the challenging matrix human blood plasma is described. The material was created via the modification of PMMA with supramolecular binding sites. The polymer exhibits excellent selectivity and reversibility including continuous expansion-contraction cycles.

 
Advisor
SchoolPORTLAND STATE UNIVERSITY
SourceDAI/B 70-02, p. , Apr 2009
Source TypeDissertation
SubjectsPolymer chemistry
Publication Number3346721
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