Response to Intervention (RtI) is a current reform initiative being examined by educational think tanks, political emissaries and proponents of special interests. Essentially, RtI (Response to Intervention) is being heralded as an educational methodology to increase student achievement through systematic problem-solving and the implementation of specific interventions based on the child's individual needs. Currently, Response to Intervention advocates are utilizing a three-tier model incorporating general interventions for all students in the class followed by increasingly intensive and individualized interventions as students continue to demonstrate need. Additionally, Response to Intervention is expected to decrease the number of students referred to, and subsequently placed in, special education. The Response to Intervention initiative in the State of Indiana was to be implemented in August 2008. Developing a Response to Intervention plan is a highly individualized process depending on the needs of the school district. This study utilized a mixed research methodology incorporating both quantitative and qualitative components. Sixteen public school districts in Northwest Indiana were contacted and the progress of thirteen districts were documented in order to develop an informational resource collection that can be utilized by other states attempting to implement Response to Intervention on a large-scale basis.