Percutaneous coronary intervention (PCI) is a key clinical tool for assessing and accessing the vasculature of the heart. In the United States over 1,000,000 PCIs take place yearly. PCI requires the insertion of a femoral artery sheath to gain access to the vasculature of the heart. On completion of the procedure, the femoral arterial sheath is removed. Physicians, nurses, and specially trained individuals can remove femoral artery sheaths. Many methods are employed to remove these sheaths including manual compression of the femoral artery, mechanical compression of the femoral artery, and vascular closure devices. An extensive literature search was completed to determine the method of femoral arterial sheath removal. Outcomes that were analyzed were time to hemostasis, time to ambulation, and the rate of vascular complications. Based on the literature, vascular closure devices are the preferred method to remove femoral arterial sheaths. VCDs have the same rate of vascular complications as other methods and allow the patient to ambulate early. Based on these findings, a guideline was developed to guide practice.