In 1494, French troops invaded Italy, sparking a series of wars fought on Italian soil involving almost all the major European powers and were at their most intense from 1500-1530, roughly the same time as France's occupation of the Duchy of Lombardy and its capital city, Milan. My dissertation examines the social and cultural repercussions of a prolonged foreign occupation of one of Europe's largest cities during the High Renaissance. I examine various elements of life during this period of war and occupation, paying particular attention to Milan, but not ignoring other cities in the duchy or the experiences and reactions of the French. Chapter 1 questions historians' reception of the canonical narrative of this period and argues for a reappraisal of the value of vernacular chronicles and other narratives as sources particularly attuned to citizens' experiences. Subsequent chapters each treat an aspect of the encounter between the French occupiers and Milanese society. Chapter 2 highlights the damages caused by the wars and the spectrum of responses to these challenges to public health, physical integrity, and identity. Chapter 3 shows how Italian prophecy became a leading force in debates over the reach of papal power, culminating in the French-sponsored anti-papal church council that took refuge in Milan. Two Milanese prophets, one pro- and one anti-French, illustrate the mixing of religion and polemics in occupied Milan. Chapter 4 demonstrates the friction between encouraging the flourishing of the Lombard economy and the logistical and strategic impediments of war. A final chapter on the 'homefront' reception of the Italian Wars in France argues that the increasing cost of the venture and the instability it provoked domestically contributed to dissatisfaction and dissent against the king. Using a variety of sources from French and Italian archives and libraries, "French Milan" refocuses the debate over Renaissance warfare and argues for the importance of social and cultural perspectives in order to approach a fuller understanding of life during wartime in early modern Europe.