Although it is impossible to calculate the number of prostitutes in America, it is estimated that at least two million women and girls are currently working as prostitutes (Flowers, 1998, p. 15). Despite the large numbers of women in prostitution, this population goes unnoticed from a psychological treatment and research perspective. The majority of women leaving prostitution are faced with a multitude of issues including histories of abuse, trauma, substance abuse, homelessness, lack of job skills, unmet medical needs, and fear of pimps. Very few programs exist that can comprehensively and simultaneously address the needs of these women. The Purpose of this process evaluation was to assess and document the operations of all adult female residential treatment programs operating in the United States that could be identified through an internet search. Out of the six qualifying programs, four programs participated in this study, represented by their program directors. Each program director completed a 52-item questionnaire (Prostitution Treatment Program Assessment) created specifically for this study and reviewed by a panel of experts. The questionnaire explored several program components, including history of each program, program development, operation, treatment protocol, current staff members, client demographics, client perspective and general program information. The results of this in-depth, descriptive, collective case study highlighted the similarities and differences between programs, as well as various obstacles and assets to program development and operation. Results suggested that the most desirable design would be a long-term treatment program simultaneously addressing key therapeutic issues, educational components and social skills, while creating a safe and stable support system. The presence of secure funding and program flexibility also appeared to facilitate program operation.