The purpose of this qualitative multi-case study was to explore changes in prospective teachers' beliefs, attitudes, and self-efficacy with regard to science and science teaching as a result of enrolling in an elementary science methods course and examine factors that may be responsible for instigating changes. Potential differences in the extent or types of changes experienced by students who began the course with different self-efficacy beliefs and attitude and interrelationships between the three variables were also explored. Two quantitative instruments were administered to identify two students with initial negative, neutral, and positive attitudes and self efficacy beliefs for a total of six cases. Within case analysis included a descriptive case study of each participant detailing their background experiences and initial and post attitudes, self efficacy, and beliefs about science and science teaching. All qualitative data, including pre and post interviews, student artifacts, and observation data were simultaneously analyzed using the constant comparative model for each individual in order to generate thick and rich descriptions of each case. A cross case analysis between different cases was performed to determine commonalities and differences among cases. The results of this study indicated that a science methods course employing effective teaching strategies can be influential in improving pre-service teachers' attitude and self-efficacy and help better align their beliefs with recommendations of major national science education reforms. The various influential factors instrumental in producing major changes in their attitude, self-efficacy beliefs, and views included class activities, readings, videos, weekly reflections, mini and full unit development, and collaborative work with their peers. They credited these factors with allowing them to (1) view science and science teaching in a different light, (2) find science interesting and fun to learn and teach, and (3) gain confidence in their abilities to teach science in their future classrooms.