The purpose of this dissertation is to apply a biocultural model of migration to the Mexican Milwaukee community. I examine the relationship between stress, social support, acculturation, and biologic measures of stress or more specifically body mass index (BMI), blood pressure, and salivary cortisol. The first chapter summarizes what a biocultural model is and how this concept will be applied to the questions asked about stress, social support, acculturation, and biology. The second chapter is a review of the literature that explains the model used. The third chapter is an extension of the second, where a description of Mexican immigration history, acculturation, and health are used to contextualize the model. The fourth chapter describes the materials and methods, where I employ culturally relevant measures of acculturation, perceived stress, acculturative stress, and social support in a semi structured interview situation. I collected corporal measurements like weight, height, blood pressure, and explain how I collected saliva and analyzed salivary cortisol. The fifth, sixth, and seventh chapters provide the results and discussion of the study. The main findings were that women, who are mostly under the financial form of acculturative stress, use a separationist technique to deal with the influence of becoming "American" but also use integrationist techniques to function in daily life outside of the Mexican community. I show how social support mediates the stress-biology relationship. Women rely mostly upon their female family and friends. If that network is not in place, they resort to depending upon male friends for support. Women who rely more upon female family have lower stress and lower salivary cortisol concentrations. Alternatively women who rely more upon male friends have higher stress and elevated salivary cortisol concentrations. These relationships are significant for cortisol but not for blood pressure or BMI. They also hold while controlling for acculturation, socioeconomic status, and demographic variables. Furthermore, I also show that acculturation is directly related to cortisol and could be an indicator of health problems leading to depression or diabetes mellitus. The last chapter summarizes these findings and discusses implications for Mexican community health.