This study explored the preventive impact of a brief Hatha yoga program on stress-reduction and enhanced wellbeing in a sample of healthy African American college athletes. African Americans suffer higher rates of hypertension and sudden cardiac death syndrome, both linked to stress. Study design was single case, with six replications, utilizing comparison of pre- and postintervention scores on physiological and psychological indicators of distress and wellbeing. Findings were inconsistent across participants and measures, though generally included beneficial increases in positive affect (i.e., C = 0.567, Z = 2.071, p < 0.05) and perceived physical health (i.e., C = 0.489, Z = 1.721, p < 0.05). Increased fatigue over the course of the semester may have confounded results. Given the brevity and cost-effectiveness of the intervention, limited positive results suggest more intensive studies are warranted.