Innovative biomedical applications using hybrid nanoparticles
by Kim, Jason Sung, Ph.D., THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, 2008, 209 pages; 3304358

Abstract:

Nanoparticle and metal-chelate technologies can be combined to create innovative hybrid materials with versatile functions for research and clinical purposes. This dissertation addresses the novel use of hybrid inorganic/organic nanoparticles in biomedical applications, including early detection of autoimmune disease and cancer as well as purification of therapeutic proteins. In an in vivo animal model of rheumatoid arthritis (RA), fluorescent nanoparticles coated with a magnetic resonance imaging (MRI) contrast enhancing metal-chelate are used for cell specific trafficking of monocytes, which correlate with disease activity. Metal-chelate derivatized magnetic nanoparticles isolate tagged proteins, potential cancer therapeutics, from impurities generated from bacterial and mammalian cell expression systems. The novel applications of hybrid magnetic nanoparticles pursued in this dissertation have the ability to translate into new and more sensitive strategies to treat patients with chronic disease.

 
AdviserWenbin Lin
SchoolTHE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
SourceDAI/B 69-04, p. , Aug 2008
Source TypeDissertation
SubjectsInorganic chemistry; Pharmaceutical Chemistry; Pharmaceutical sciences
Publication Number3304358
Adobe PDF Access the complete dissertation:
 

» Find an electronic copy at your library.
  Use the link below to access a full citation record of this graduate work:
  http://gateway.proquest.com/openurl%3furl_ver=Z39.88-2004%26res_dat=xri:pqdiss%26rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation%26rft_dat=xri:pqdiss:3304358
  If your library subscribes to the ProQuest Dissertations & Theses (PQDT) database, you may be entitled to a free electronic version of this graduate work. If not, you will have the option to purchase one, and access a 24 page preview for free (if available).

About ProQuest Dissertations & Theses
With over 2.3 million records, the ProQuest Dissertations & Theses (PQDT) database is the most comprehensive collection of dissertations and theses in the world. It is the database of record for graduate research.

The database includes citations of graduate works ranging from the first U.S. dissertation, accepted in 1861, to those accepted as recently as last semester. Of the 2.3 million graduate works included in the database, ProQuest offers more than 1.9 million in full text formats. Of those, over 860,000 are available in PDF format. More than 60,000 dissertations and theses are added to the database each year.

If you have questions, please feel free to visit the ProQuest Web site - http://www.proquest.com - or call ProQuest Hotline Customer Support at 1-800-521-3042.