This study explored discrimination stress (negative psychological effects associated with perceived negative attitudes, prejudice and discrimination) among cultural minority members in the United States. Previous research suggests that severe acculturative stress leads to increased depression, anxiety and suicidality. A major component of acculturative stress is posited to be the stress caused by discrimination. Although the body of acculturative stress research has been growing, literature shows that a measurement gap exists for discrimination stress, which is an important topic to address in today's changing multicultural landscape. Discrimination stress may be faced by various immigrant and non-immigrant cultural minority groups, including Arab, Latino, African, Asian, Eastern European, African Americans, Latino, religious minority (Muslim) and sexual minority members. The experience of discrimination is expected to lead to deleterious psychological effects. However, it was also posited to lead to resilience and growth in cultural minority members. This qualitative analysis used interview data to add to the phenomenology of discrimination stress. This study explored themes associated with discrimination stress, acculturative stress, and growth using grounded theory analysis. Expected themes associated with discrimination stress included acculturative stress, depression, anxiety and low self-esteem. Seven domains were found in this study which included: acculturation, discrimination, experiences of discrimination, psychological sequelae of discrimination/acculturation (discrimination stress), behavioral sequelae of discrimination stress, coping strategies and growth. Furthermore, 16 general themes, 23 typical themes, 30 major variant themes and 61 minor variant themes were determined following grounded theory analysis.